ABN458
Anti-Choline Transporter Antibody
from rabbit, purified by affinity chromatography
Sinonimo/i:
High affinity choline transporter 1, Hemicholinium-3-sensitive choline transporter, CHT, Solute carrier family 5 member 7
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
human, rat, mouse
tecniche
immunohistochemistry: suitable (paraffin)
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... SLC5A7(60482)
Descrizione generale
The protein named Choline Transporter or Hemicholinium-3-sensitive choline transporter (CHT), and encoded by the gene SLC5A7/CHT1, is the high affinity choline transporter in neurons. Choline is the rate limiting step in acetylcholine synthesis an important neurotransmitter. Acetylcholine is a neurotransmitter of the central and peripheral nervous system that regulates a variety of autonomic, cognitive, and motor functions. The choline transporter is localized to the cell membrane and is expressed in cholinergic neurons particularly in the putamen, spinal cord and medulla. Defects in the choline transporter may be associated with a syndrome named distal spinal muscular atrophy with vocal cord paralysis. The choline transporter protein is a Na+ and Cl- dependent transporter that can be inhibited by nanomolar concentrations of the chemical compound hemicholinium 3, a compound often used to deplete acetylcholine stores.
Immunogeno
GST-tagged recombinant protein corresponding to the C-terminus of human Choline Transporter.
Applicazioni
Anti-Choline Transporter Antibody is a highly specific rabbit polyclonal antibody, that targets Choline Transporter & has been tested in western blotting & IHC (Paraffin).
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Choline Transporter in rat spinal cord and human cerebral cortex tissue.
Qualità
Evaluated by Western Blotting in rat spinal cord tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Choline Transporter in 10 µg of rat spinal cord tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected Choline Transporter in 10 µg of rat spinal cord tissue lysate.
Descrizione del bersaglio
~70-75 kDa observed. Uniprot states MW at ~63kDa but lists one glycosylation site which adds ~5kDa to the total MW.
Linkage
Replaces: AB5960;AB5966
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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Ajeesh Koshy Cherian et al.
Neurochemistry international, 108, 410-416 (2017-06-05)
The synaptic uptake of choline via the high-affinity, hemicholinium-3-dependent choline transporter (CHT) strongly influences the capacity of cholinergic neurons to sustain acetylcholine (ACh) synthesis and release. To advance research on the impact of CHT capacity in humans, we established the
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