ABN161-I

Anti-pan Neurexin-1 Antibody

from rabbit, purified by affinity chromatography

• Sinonimo/i: Neurexin-1, Neurexin-1-alpha, Neurexin I-alpha
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Livello qualitativo: 100
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Purificato mediante: affinity chromatography
• Reattività contro le specie: mouse, rat, human
• Reattività contro le specie (prevista in base all’omologia): bovine (based on 100% sequence homology)
• tecniche: immunohistochemistry: suitable (paraffin); western blot: suitable
• N° accesso NCBI: NP_796258
• N° accesso UniProt: Q9CS84
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: mouse ... Nrxn1(18189)

Descrizione

Descrizione generale

Neurexin-1 (UniProt Q9CS84; also known as Neurexin I-alpha, Neurexin-1-alpha) is encoded by the Nrxn1 (also known as Kiaa0578) gene (Gene ID 18189) in murine species. Neurexin (NRXN) is a presynaptic single pass transmembrane protein that assists in joining neurons together at the synapse. Neurexins mediate signaling across the synapse and neural networks by specifying synpatic function. Mutations in the genes encoding for neurexins are implicated in autism, schizphrenia, and nicotine dependence. There are two classifications of neurexins, α-NRXNs and β-NRXNs. The α-NRXNs are larger and have different amino-terminal extracellular sequences than β-NRXNs. β-NRXNs act as receptors for neuroligin and have been found to play a role in angiogenesis.

Specificità

Expected to react with all neurexin-1-alpha and neurexin-1-beta spliced isoforms of murine, human, and rat species, as this polyclonal antibody targets the C-terminal end cytoplasmic sequence that is not affected by alternative splicings (Missler, M., and Südhof, T.C. (1998). Trends Genet. 14(1):20-26). Cross-reactivities toward alpha and beta isoforms of neurexin-2 and neurexin-3 are also likely, although the C-termminal sequence is not 100% conserved among neurexin-1, neurexin-2 and neurexin-3.

Immunogeno

Epitope: Near C-terminus.

KLH-conjugated linear peptide corresponding to a cytoplasmic domain sequence near the C-teminus of mouse neurexin-1.

Applicazioni

Anti-pan Neurexin-1 Antibody detects level of pan Neurexin-1 and has been published and validated for use in Western Blotting, Immunohistochemistry (Paraffin).

Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected Neurexin-1 in mouse, rat, and human cerebral cortex tissue sections.

Research Category
Neuroscience

Research Sub Category
Developmental Neuroscience

Qualità

Evaluated by Western Blotting in mouse brain tissue lysate.

Western Blotting Analysis: 0.2 µg/mL of this antibody detected Neurexin-1 in 10 µg of mouse brain tissue lysate.

Descrizione del bersaglio

~170/55/40 kDa observed. Varible depending on the isoform(s) present in the test sample(s).

Linkage

Replaces: ABN161

Stato fisico

Affinity purified

Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Altre note

Concentration: Please refer to lot specific datasheet.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable