AB2267
Anti-LCN2 Antibody
from rabbit, purified by affinity chromatography
Sinonimo/i:
lipocalin 2, migration-stimulating factor inhibitor, siderocalin, Oncogene 24p3, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, lipocalin 2 (oncogene 24p3), neutrophil gelatinase-associated lipocalin, Lipocalin-2
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About This Item
Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Prodotti consigliati
Origine biologica
rabbit
Livello qualitativo
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Purificato mediante
affinity chromatography
Reattività contro le specie
human
Reattività contro le specie (prevista in base all’omologia)
rat (based on 100% sequence homology), bovine (based on 100% sequence homology), mouse (based on 100% sequence homology)
tecniche
immunohistochemistry: suitable
western blot: suitable
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... LCN2(3934)
Descrizione generale
LCN2 (also known as Neurophil Gelatinase-Associated Lipocalin or NGAL) belongs to a superfamily of lipocalins, a collection of small, diversely functional, extracellular proteins. NGAL is secreted from neutrophil granules in three different forms; a monomer of 25 kDa, a disulfide-linked homodimer at 46 kDa, and a disulfide-linked heterodimer with MMP-9 at 135-kDa. It is widely known to induce development of kidney epithelia, to bind and traffic iron, and to act as a molecular signal under inflammatory conditions, such as Crohn’s Disease. Multiple carcinoma studies have also shown elevated expression levels of LCN2 in several different human tumors affecting such organs as: colon, lung, breast, ovaries and pancreas. Additionally, there has been great interest in this protein as a possible marker for: onset of Acute Kidney Injury following cardiac surgery, the progression of Chronic Kidney Disease (CKD), and the survival chances of patients with Chronic Heart Failure (CHF).
Specificità
This antibody recognizes LCN2.
Immunogeno
Epitope: Mature chain
KLH-conjugated linear peptide corresponding to the mature chain of human LCN2.
Applicazioni
Anti-LCN2 Antibody detects level of LCN2 & has been published & validated for use in WB, IH.
Immunohistochemistry Analysis: A 1:200 dilution of Anti-LCN2 antibody from a previous lot detected LCN2 in human spleen tissue.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurodegenerative Diseases
Neurodegenerative Diseases
Qualità
Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected LCN2 in 10 µg of human kidney tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected LCN2 in 10 µg of human kidney tissue lysate.
Descrizione del bersaglio
LCN2 band observed at 25 kDa Heavy concentration of tissue lysate and a 5 minute exposure time were used to generate the band of interest.
Stato fisico
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
Stoccaggio e stabilità
Stable for 1 year at 2-8°C from date of receipt.
Risultati analitici
Control
Human kidney tissue lysate
Human kidney tissue lysate
Altre note
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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