Passa al contenuto
Merck
Tutte le immagini(2)

Documenti fondamentali

AB10526

Sigma-Aldrich

Anti-COX4 Antibody

from rabbit, purified by affinity chromatography

Sinonimo/i:

cytochrome c oxidase subunit IV isoform 1, cytochrome c oxidase subunit IV1, Cytochrome c oxidase polypeptide IV, cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(2)

About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Purificato mediante

affinity chromatography

Reattività contro le specie

human

Confezionamento

antibody small pack of 25 μg

tecniche

immunohistochemistry: suitable (paraffin)
western blot: suitable

N° accesso NCBI

NP_001852

N° accesso UniProt

P13073

Condizioni di spedizione

ambient

Temperatura di conservazione

2-8°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... COX4I1(1327)

Descrizione generale

Cytochrome C oxidase subunit 4 (COX4), is one of 13 subunits of cytochrome c oxidase. Cytochrome c oxidase is responsible for catalyzing the last step of electron transfer through the respiratory chain on the mitochondrial inner membrane. COX4 assembles into sub-complexes with other subunits of cytochrome c oxidase and may represent a rate-limiting intermediate.

Specificità

Other homologies: Rat and mouse (59% sequence homology).

Immunogeno

KLH-conjugated linear peptide corresponding to human COX4.

Applicazioni

Anti-COX4 Antibody detects level of COX4 & has been published & validated for use in WB, IH(P).
Immunohistochemistry Analysis: A 1:500 dilution from a previous lot detected COX4 in normal human cardiac muscle tissue.
Research Category
Apoptosis & Cancer
Research Sub Category
Apoptosis - Additional

Qualità

Evaluated by Western Blot in human fetal skeletal muscle tissue lysate.

Western Blot Analysis: 0.1 µg/mL of this antibody detected COX4 in 10 µg of human fetal skeletal muscle tissue lysate.

Descrizione del bersaglio

~17 kDa observed.
A non-specific band may be observed at ~58 kDa

Stato fisico

Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Risultati analitici

Control
Human fetal skeletal muscle tissue lysate

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Non trovi il prodotto giusto?  

Prova il nostro Motore di ricerca dei prodotti.

Raccomandato

N° Catalogo
Descrizione
Determinazione del prezzo

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Ana Andres-Hernando et al.
American journal of physiology. Renal physiology, 317(4), F941-F948 (2019-08-15)
Obesity and metabolic syndrome are well-known risk factors for chronic kidney disease (CKD); however, less is known about the mechanism(s) by which metabolic syndrome might accelerate kidney disease. We hypothesized that metabolic syndrome should accelerate the development of kidney disease
Shekoufeh Almasi et al.
The Journal of biological chemistry, 293(10), 3637-3650 (2018-01-19)
A lack of effective treatment is one of the main factors contributing to gastric cancer-related death. Discovering effective targets and understanding their underlying anti-cancer mechanism are key to achieving the best response to treatment and to limiting side effects. Although
Astrid Heim et al.
Nucleic acids research, 42(12), 7833-7850 (2014-06-11)
The Fe(II) and 2-oxoglutarate dependent oxygenase Jmjd6 has been shown to hydroxylate lysine residues in the essential splice factor U2 auxiliary factor 65 kDa subunit (U2AF65) and to act as a modulator of alternative splicing. We describe further evidence for
Seung-Min Lee et al.
Biogerontology, 13(5), 525-536 (2012-09-14)
Carbohydrate metabolism changes during cellular senescence. Cytosolic malate dehydrogenase (MDH1) catalyzes the reversible reduction of oxaloacetate to malate at the expense of reduced nicotinamide adenine dinucleotide (NADH). Here, we show that MDH1 plays a critical role in the cellular senescence

Articoli

Loading controls for western blotting

Loading controls in western blotting application.

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.