869001-M

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade

Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, CAS 9002-68-0, is a native pituitary protein that regulates Sertoli cells by acting on G-protein-linked cell surface FSH receptors.

• Sinonimo/i: Follicle Stimulating Hormone, Human Pituitary, Iodination Grade, Follitropin, hFSH
• Numero CAS: 9002-68-0
• Numero MDL: MFCD00131099
• Codice UNSPSC: 12352202
• NACRES: NA.32

Proprietà

• Origine biologica: human pituitary glands
• Livello qualitativo: 200
• Sterilità: non-sterile
• Nome Commerciale: Calbiochem^®
• Saggio: ≥90%
• Forma fisica: lyophilized solid
• Attività specifica: ≥2000 IU/mg
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Impurezze: ≤0.1% hCG; ≤0.5% hLH, hTSH
• pI: 4.1
• Solubilità: PBS: soluble
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Follicle-stimulating hormone (FSH) belongs to the family of glycoprotein hormones. It is synthesized in the gonadotrophs present in the pituitary gland. FSH contains non-covalently associated α- and β-subunits and is a disulfide-rich heterodimer.

Research area: Cell Signaling

Azioni biochim/fisiol

Follicle-stimulating hormone (FSH) participates in the regulation of reproduction in mammals. It exerts its effects through a G-protein-coupled receptor known as follicle-stimulating hormone receptor (FSHR) that is located on the granulosa cells of the ovaries and Sertoli cells of the testes. FSH plays a role in the maturation of ovarian follicles in females and supports spermatogenesis by activating Sertoli cell proliferation in males. The interaction of FSH with its receptor FSH-R leads to the activation of G-protein coupled receptors/cyclic adenosine monophosphate (cAMP)/protein kinase A pathways to transmit intracellular signals.

Attenzione

Toxicity: Carcinogenic / Teratogenic (D)

Nota sulla preparazione

Prepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Costrici, N., et al. 1995. Endocrinology136, 4705.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable