8.55004

Rink Amide AM resin (200-400 mesh)

Novabiochem^®

• Sinonimo/i: 4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucylaminomethyl resin
• Codice UNSPSC: 12352111
• NACRES: NA.22

Proprietà

• Livello qualitativo: 400
• Nome Commerciale: Novabiochem^®
• Forma fisica: beads
• Impiego in reazioni chimiche: reaction type: Fmoc solid-phase peptide synthesis
• Produttore/marchio commerciale: Novabiochem^®
• applicazioni: peptide synthesis
• Gruppo funzionale: amine
• Temperatura di conservazione: 2-30°C

Descrizione

Descrizione generale

This support comprises the modified Rink amide linker attached via norleucine to aminomethylpolystyrene, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.

Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins

Applicazioni

• Second generation amphiphilic poly-lysine dendrons inhibit glioblastoma cell proliferation without toxicity for neurons or astrocytes: Uses Rink Amide AM resin with a 0.71mmol/g loading capacity for synthesizing amphiphilic dendritic amides. (Janiszewska et al., 2016).


• The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides: Describes peptide synthesis on Rink Amide AM resin with a 0.79 mmol/g loading capacity. (Eggimann et al., 2015).

Linkage

Replaces: 01-64-0038

Risultati analitici

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.80 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH₂Cl₂): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.1 ml/g
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene-1 % DVB), 200 -400 mesh.

Note legali

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable