5.30537

JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1

• Sinonimo/i: JmjC Histone Demethylase Inhibitor, n-Octyl-IOX1, KDM4 Inhibitor
• Formula empirica (notazione di Hill): C₁₈H₂₃NO₃
• Numero CAS: 1586038-75-6
• Peso molecolare: 301.38
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Livello qualitativo: 100
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: gray-green
• Solubilità: DMSO: 5 mg/mL
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

A cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC₅₀ = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC₅₀ = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.

A cell-permeable, non-toxic, n-octyl ester form of 5-carboxy-8-hydroxyquinoline (IOX1, Cat. No. 420201) that acts as a superior inhibitor of Jumonji C domain histone lysine demethylase. Shown to be about 30 fold more potent than IOX1 (EC₅₀ = 3.8 µM for KDM4A in HeLa cells vs. 100 µM for IOX1). Inhibits the H3K9 me3 demethylation activity of KDM4C (IC₅₀ = 3.9 µM in ALPHA Screen assay). Exhibits greater stability to hydrolysis in the ALPHA Screen buffer.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
KDM4

Reversible: yes

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Schiller, R., et al. 2014. ChemMedChem.9,566.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable