520219

PPACK II trifluoroacetate salt

≥95% (HPLC), solid, kallikrein inhibitor, Calbiochem^®

• Sinonimo/i: PPACK II, Trifluoroacetate Salt
• Formula empirica (notazione di Hill): C₂₅H₃₃ClN₆O₃ · 2C₂HF₃O₂
• Numero CAS: 74392-49-7
• Peso molecolare: 729.07
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• product name: PPACK II, Trifluoroacetate Salt, Potent and specific irreversible inhibitor of plasma and glandular kallikreins.
• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; desiccated
• Colore: off-white
• Solubilità: water: 100 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C25H33ClN6O3/c26-16-22(33)20(12-7-13-30-25(28)29)31-21(15-18-10-5-2-6-11-18)24(35)32-23(34)19(27)14-17-8-3-1-4-9-17/h1-6,8-11,19-21,31H,7,12-16,27H2,(H4,28,29,30)(H,32,34,35)/t19-,20+,21+/m1/s1; UFXAQJOOAQICNE-HKBOAZHASA-N

Descrizione

Descrizione generale

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Also available as a 10 mM solution in H₂O (Cat. No. 508573).

Potent and specific irreversible inhibitor of plasma and glandular kallikreins. Inhibits the cleavage of atrial naturiuretic peptide (ANP 1-126) by kallikreins. Also inhibits adrenal kininogenase, a kallikrein-like enzyme.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Plasma and glandular kallikreins

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Standard Handling (A)

Sequenza

H-D-Phe-Phe-Arg-chloromethylketone, 2TFA

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.

Altre note

Byrne, R.E., and Scanu, A.M. 1989. J. Lipid Res. 30, 109.
Scicli, G., et al. 1989. Adv. Exp. Med. Biol.247B, 217.
Gibson, T.R., et al. 1987. Endocrinology120, 764.
Kettner, G., and Shaw, E. 1981. Methods Enzymol.80, 826.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable