5.04042

Doxorubicin Hydrochloride

InSolution, ≥98%

• Sinonimo/i: InSolution Doxorubicin, Hydrochloride, Adriamycin, HCl, 14-Hydroxydaunomycin, HCl
• Formula empirica (notazione di Hill): C₂₇H₂₉NO₁₁ · xHCl
• Numero CAS: 25316-40-9
• Peso molecolare: 543.52 (free base basis)
• Numero MDL: MFCD00077757
• Codice UNSPSC: 12352101

Proprietà

• Livello qualitativo: 200
• Saggio: ≥98% (HPLC)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles; protect from light
• Temperatura di conservazione: −70°C
• InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10?,13?,15-,17?,22?,27-;/m0./s1; MWWSFMDVAYGXBV-FGBJBKNOSA-N

Descrizione

Descrizione generale

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl in H₂O.

An anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC₅₀ = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.

Ricostituzione

Following initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.

Altre note

A′Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol.13, 726.
Nooter, K., et al. 1995. Br. J. Cancer71, 556.
Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
Anderson, R.D., et al. 1993. Mutat. Res.294, 215.
Hershko, C., et al. 1993. J. Lab. Clin. Med.122, 245.
Jongmans, W., et al. 1993. Mutat. Res.294, 207.
O′Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc.270, 2089.
Theyer, G., et al. 1993. J. Urol.150, 1544.
Tritton, T.R., and Yee, G. 1982. Science217, 248.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany