345733-M

Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk

Contains mainly N-acetylneuraminic acid.

• Sinonimo/i: Ganglioside GM₃, Monosialo, Ammonium Salt, Bovine Milk, Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, NH₄
• Formula empirica (notazione di Hill): C₆₄H₁₁₈N₂O₂₁ · NH₄
• Peso molecolare: 1269.66
• Codice UNSPSC: 12352211

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (TLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: white
• Solubilità: chloroform/methanol (2:1): soluble
• Temperatura di conservazione: −20°C

Descrizione

Descrizione generale

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in biosynthesis and metabolism of higher gangliosides. GM₃ is reported to inhibit EGF-receptor tyrosine kinase activity in whole cells and plasma membranes, and in detergent micelles. Inhibits protein kinase C activity in both cytosolic and total particulate fractions (IC₅₀ = 100 - 115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

Contains mainly N-acetylneuraminic acid. GM₃ and its derivatives play important roles in immunoregulation and in the biosynthesis and metabolism of higher gangliosides. Inhibits protein kinase C activity in both cytosolic and total particulate fractions(IC₅₀ = 100-115 µM). Induces the down-modulation of CD4 molecules. Useful as a substrate for neuraminidases. Binds EGF and FGF.

M.W. 1198.5 (based on stearoyl - 18:0).

Azioni biochim/fisiol

Primary Target
Protein kinase C, EGF-receptor tyrosine kinase

Target IC₅₀: 100 - 115 µM inhibiting protein kinase C activity in both cytosolic and total particulate fractions

Attenzione

Toxicity: Irritant (B)

Altre note

Katoh, N. 1995. Life Sci. 56, 157.
Sorice, M., et al. 1995. Scand. J. Immunol. 41, 148.
Kadowaki, H., and Grant, M.A. 1994. J. Biol. Chem. 269, 14931.
Muthing, J., et al. 1994. J. Biochem. (Tokyo) 116, 64.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable