341273

Factor D, Human

Factor D, Human, is a native single-chain glycoprotein with serine protease activity. Cleaves, and thus activates, Factor B during activation of complement via the alternative pathway.

• Sinonimo/i: C3 Activator Convertase, Adipsin
• Codice UNSPSC: 12352202

Proprietà

• Livello qualitativo: 100
• Saggio: ≥90% (SDS-PAGE)
• Forma fisica: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; avoid repeated freeze/thaw cycles
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −70°C

Descrizione

Descrizione generale

Native factor D from human serum. Single-chain glycoprotein composed of 222 amino acids present in normal human serum at about 1.4 µg/ml. Serine protease that cleaves, and thus activates, Factor B during activation of complement via the alternative pathway. Has recently been shown to be identical to adipsin, a serine protease secreted into the bloodstream by adipocytes.

Native factor D from human serum. Single-chain glycoprotein composed of 222 amino acids, present in normal human serum at about 1.4 µg/ml. Serine protease that cleaves, and thus activates, Factor B during activation of complement via the alternative pathway. Has recently been shown to be identical to adipsin, a serine protease secreted into the bloodstream by adipocytes.

Azioni biochim/fisiol

IgG, IgA, IgM, Factor H, Factor B, or albumin: ≤trace amounts

Attenzione

Toxicity: Standard Handling (A)

Stato fisico

In PBS, pH 7.2.

Nota sulla preparazione

Prepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Ricostituzione

Following initial thaw, aliquot and freeze (-70°C).

Altre note

Jing, H., et al. 1999. EMBO J.18, 804.
Volankis, J.E., et al. 1985. N. Engl. J. Med. 312, 395.
Niemann, M.A., et al. 1984. J. Immunol. 132, 809.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Esclusione di responsabilità

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable