298711

Diethyl Pyrocarbonate

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca²⁺ permeability of SR vesicles.

• Sinonimo/i: Diethyl Pyrocarbonate, Diethyl Oxydiformate, DEPC
• Formula empirica (notazione di Hill): C₆H₁₀O₅
• Numero CAS: 1609-47-8
• Peso molecolare: 162.14
• Numero MDL: MFCD00009106
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (titration)
• Stato: liquid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: clear colorless
• Solubilità: chloroform: soluble; ethanol: soluble
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3; FFYPMLJYZAEMQB-UHFFFAOYSA-N

Descrizione

Descrizione generale

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca²⁺ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Inhibits ryanodine binding to ryanodine/Ca²⁺ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Azioni biochim/fisiol

Cell permeable: no

Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle

Product does not compete with ATP.

Reversible: no

Attenzione

Toxicity: Harmful (C)

Altre note

Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Consigli di prudenza: P264 - P270 - P301 + P312 - P501
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 156.2 °F - closed cup
• Punto d’infiammabilità (°C): 69 °C - closed cup