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239765

Sigma-Aldrich

Cycloheximide

InSolution, 100 mg/mL in DMSO, Suitable for cell culture

Sinonimo/i:

InSolution Cycloheximide

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About This Item

Formula empirica (notazione di Hill):
C15H23NO4
Numero CAS:
66-81-9
Peso molecolare:
281.35
Numero MDL:
MFCD00082346
Codice UNSPSC:
12352111

Livello qualitativo

100

Forma fisica

solution

Produttore/marchio commerciale

Calbiochem®

Concentrazione

100 mg/mL in DMSO

Solubilità

DMSO: soluble

Temperatura di conservazione

2-8°C

InChI

1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
YPHMISFOHDHNIV-FSZOTQKASA-N

Descrizione generale

A convenient ready-to-use form of Cycloheximide (Cat. No. 239763). An anti-fungal antibiotic that inhibits protein synthesis in eukaryotes but not in prokaryotes. Interacts directly with the translocase enzyme, interfering with the translocation step. Also inhibits cell-free protein synthesis in eukaryotes. Competitively inhibits hFKBP12 (Ki = 3.4 µM). Triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt′s lymphoma cells, and a variety of other cell types, including rodent macrophages. Induces DNA fragmentation in macrophages, but inhibits DNA cleavage in rat thymocytes treated with thapsigargin, methylprednisolone, and ionomycin. Rapidly destroyed in alkaline solutions.

Azioni biochim/fisiol

Primary Target
hFKBP12

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Highly Toxic & Carcinogenic / Teratogenic (I)

Stato fisico

A 100 mg/ml solution of Cycloheximide (Cat. No. 239763) in DMSO (sterile-filtered).

Ricostituzione

Following initial use, aliquot and refrigerate (4°C).

Altre note

Christner, C., et al. 1999. J. Med. Chem.42, 3615.
Lu, Q. and Mellgreen,R.L. 1996. Arch. Biochem. Biophys.334, 175.
Chow, S.C., et al. 1995. Exp. Cell Res.216, 149.
Waring, P. 1990. J. Biol. Chem.265, 14476.
Obrig, T.G., et al. 1971. J. Biol. Chem.246, 174.
Pestka, S. 1971. Annu. Rev. Microbiol.25, 487.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Indicazioni di pericolo

H301 - H341 - H360D - H412

Classi di pericolo

Acute Tox. 3 Oral - Aquatic Chronic 3 - Muta. 2 - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Elenchi normativi

Forniamo informazioni su eventuali restrizioni prevalentemente per i prodotti chimici. Per altre tipologie di prodotto siamo in grado di fornire soltanto informazioni limitate. Nessuna segnalazione significa che nessuno dei componenti è citato in un elenco. È dovere dell’utilizzatore assicurarsi che il prodotto venga impiegato in maniera sicura e a norme di legge.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificati d'analisi (COA)

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