208922-M

CaMKII Inhibitor, CK59

The CaMKII Inhibitor, CK59, also referenced under CAS 140651-18-9, controls the biological activity of CaMKII. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• Sinonimo/i: CaMKII Inhibitor, CK59, 2-(2-Hydroxyethylamino)-6-aminohexylcarbamic acid tert-butyl ester-9-isopropylpurine, CK59
• Formula empirica (notazione di Hill): C₂₁H₃₇N₇O₃
• Numero CAS: 140651-18-9
• Peso molecolare: 435.56
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Forma fisica: semisolid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: yellow
• Solubilità: DMSO: 10 mg/mL
• Temperatura di conservazione: 2-8°C
• InChI: 1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,16H,(H5,10,11,14,15); AYZRKFOEZQBUEA-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable Olomoucine (Cat. Nos. 495620 & 495624) analog that acts as a CaMKII inhibitor (IC₅₀<10 µM) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 µM) and GLUT4 membrane translocation (IC₅₀ = 100 µM) in 3T3-L1 adipocytes.

A cell-permeable Olomoucine analog that acts as a CaMKII inhibitor (IC₅₀<10 M) and inhibits insulin-stimulated glucose uptake (IC₅₀ ≤5 M) and GLUT4 membrane translocation (IC₅₀ = 100 M) in 3T3-L1 adipocytes.

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution aliquot, and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Altre note

Konstantopoulos, N., et al. 2007. Endocrinology, 148, 374.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable