1.07185

Pepsin

(from porcine gastric mucosa) 0.7 FIP-U/mg for biochemistry EC 3.4.23.1

• Sinonimo/i: Pepsin
• Numero CAS: 9001-75-6
• Peso molecolare: 35000
• Numero MDL: MFCD00081840
• Codice UNSPSC: 12352204
• Numero indice EU: 232-629-3
• NACRES: NA.21

Proprietà

• pH: 4.0-5.0 (20 °C, 10 g/L in H₂O)
• Solubilità: 10 g/L
• Densità bulk: 380‑420 kg/m³
• Temperatura di conservazione: 2-30°C

Descrizione

Applicazioni

Pepsin has been used in the preparation of simulated gastric fluid to perform in vitro gastric digestion.

Azioni biochim/fisiol

Pepsin is a component of gastric juice and is associated with protein digestion. It is an endopeptidase that catalyzes the degradation of proteins into peptides and amino acids for small intestinal absorption. Pepsin is released as a zymogen (pepsinogen) by the chief cells of the gastric lining. It gets activated by the acidic environment created by the hydrochloric acid (HCl) of gastric juice. Pepsin is active at pH 1.5 to 2, in the stomach. It is involved in the conversion of food bolus into chyme. It is associated with laryngopharyngeal reflux (LPR) indicated by chronic cough, mild dysphagia, hoarseness, and non-productive throat clearing.

Risultati analitici

Appearance: fine, slightly yellow powder
Activity/FIP (Hemoglobin; pH 1.6; 25 °C): ≥ 0.70 FIP-U/mg
pH-value (1 %; water): 4.0 - 5.0
Water (according to Karl Fischer): ≤ 6.0 %

Informazioni sulla sicurezza

• Pittogrammi: GHS07,GHS08
• Avvertenze: Danger
• Indicazioni di pericolo: H315 - H319 - H334 - H335
• Consigli di prudenza: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classi di pericolo: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable