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Merck
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Key Documents

09-268

Sigma-Aldrich

Anti-TKS5 (SH3 #4) Antibody

from rabbit

Sinonimo/i:

Adaptor protein TKS5, Five SH3 domain-containing protein, SH3 and PX domains 2A, SH3 multiple domains 1, SH3 multiple domains protein 1, five SH3 domains

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About This Item

Codice UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

100

Forma dell’anticorpo

purified antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Reattività contro le specie

mouse, human

tecniche

immunocytochemistry: suitable

N° accesso NCBI

NM_014631.2

N° accesso UniProt

O89032

Condizioni di spedizione

wet ice

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... SH3PXD2A(9644)

Descrizione generale

Tks5 (previously known as Fish), is a large scaffolding protein with one amino-terminal PX domain and five SH3 domains. It is cytoplasmic in normal fibroblasts. In Src-transformed cells, Tks5 localizes to podosomes. The coexpression of Tks5 and constitutively active Src in epithelial cancer cells resulted in the appearance of podosomes/invadopodia. Cells with reduced Tks5 expression are poorly invasive through matrigel. Tks5 is expressed and localized to podosomes/invadopodia in some invasive human cancer cell lines and tumor tissue, particularly breast cancers and melanomas. Thus, Tks5 appears to be required for podosome/invadopodia formation and for invasion of some cancer cells.

Immunogeno

Epitope: 833-892 aa
Recombinant Protein, aa: 833-892

Applicazioni

Anti-TKS5 (SH3 #4) Antibody is an antibody against TKS5 (SH3 #4) for use in IC.
Research Category
Cell Structure
Research Sub Category
Cytoskeletal Signaling

Qualità

Evaluated by immunocytochemistry on mouse 3T3-Src(Y527F) cells.

Descrizione del bersaglio

130-150 kDa Uncharacterized bands(s) may be observed in some cell lysates.

Stato fisico

Format: Purified
Protein A purified
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.

Stoccaggio e stabilità

Maintain at 2-8°C in undiluted aliquots for up to 1 year after date of receipt.

Risultati analitici

Control
Mouse 3T3-Src(Y527F) cells

Altre note

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Pilar Cejudo-Martin et al.
PloS one, 9(9), e107674-e107674 (2014-09-27)
Tks5 is a scaffold protein and Src substrate involved in cell migration and matrix degradation through its essential role in invadosome formation and function. We have previously described that Tks5 is fundamental for zebrafish neural crest cell migration in vivo.
Lidia Chellini et al.
Matrix biology : journal of the International Society for Matrix Biology, 81, 17-33 (2018-10-28)
The invasive phenotype of serous ovarian cancer (SOC) cells is linked to the formation of actin-based protrusions, invadopodia, operating extracellular matrix (ECM) degradation and metastatic spread. Growth factor receptors might cause engagement of integrin-related proteins, like the polarity protein IQ-domain
Cameron P Bracken et al.
The EMBO journal, 33(18), 2040-2056 (2014-07-30)
The microRNAs of the miR-200 family maintain the central characteristics of epithelia and inhibit tumor cell motility and invasiveness. Using the Ago-HITS-CLIP technology for transcriptome-wide identification of direct microRNA targets in living cells, along with extensive validation to verify the

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