03-185

Histone H2B human recombinant

• Codice UNSPSC: 12352203
• eCl@ss: 32160405
• NACRES: NA.84

Proprietà

• Forma dell’anticorpo: purified antibody
• Livello qualitativo: 100
• Saggio: >50% (SDS-PAGE)
• tecniche: activity assay: suitable; western blot: suitable

Descrizione

Descrizione generale

Histone H2B is one of four core histones that form an octameric structure required for the packaging of DNA into nucleosomes, the most basic level of chromatin arrangement. Histones undergo a number of post-translational modifications (PTM) at their N- and C-terminal tails which can influence chromatin structure and stability and consequently, transcription, and DNA replication and repair. The most widely studied of these modifications are methylation, phosphorylation, and acetylation which may produce different effects on gene regulation depending on the number and pattern of modifications. Histone H2B undergoes acetylation at lysines 5, 15, and 20. It is also phosphorylated in apoptotic cells during DNA fragmentation, possibly in a caspase-dependent manner.

Human recombinant H2B expressed in E. Coli

Applicazioni

Chromatin assembly, Western blot (control), Kinase Assay

Proprietà fisiche

~17 kDa

Stato fisico

Liquid in Dulbecco′s PBS. Frozen solution.

Stoccaggio e stabilità

Stable for 12 months at -80°C from date of receipt. Avoid multiple freeze/thaw cycles.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.