03-0210-00

SMC^® Human pTau217 High Sensitivity Immunoassay Kit

kit sufficient for 96 wells

• Sinonimo/i: pTau217 Single Molecule Counting kit, pTau217 immunoassay kit, pTau217 ultra-sensitive immunoassay, phospho Tau 217 immunoassay kit
• Codice UNSPSC: 12161503
• NACRES: NA.55

Proprietà

• Descrizione: 100uL (neat Serum, 1:2 diluted Plasma or 1:4 diluted CSF samples)
• Reattività contro le specie: human
• Produttore/marchio commerciale: SMC^®
• assay range: intra-assay cv: ≤10%; (n=15); recovery range: 76-101%; (K2EDTA Plasma); recovery range: 77-94%; (CSF); recovery range: 82-126%; (Serum); sensitivity: 1.95 pg/mL; (lower limit of quantification); standard curve range: 0.49-500 pg/mL; inter-assay cv: ≤20%; (n=15)
• tecniche: single molecule counting: suitable
• input: serum; cerebrospinal fluid (CSF); plasma (K2EDTA)
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

Tau protein is primarily a structural protein in neurons of the central nervous. Found as at least six different isoforms, these proteins are thought to provide structure, enable signaling, and regulate transport. In disease states, Tau proteins can become hyperphosphorylated and create tauopathies in the form of neurofibrillary or gliofibrillary tangles commonly associated with Alzheimer’s or Parkinson’s disease. Tau protein phosphorylated at threonine-217 is referred to as Phospho-Tau217 (pTau217). pTau217 is thought to be a promising marker for Alzheimer’s disease as it can be detected in serum or plasma and is strongly associated with physiological brain changes.


Research category : Neuroscience

Research sub-category : Alzheimer′s DiseaseAging, Nervous System, Neurodegenerative Diseases, Neuroscience

Specificità

This assay was tested for cross-reactivity with pTau181 and pTau231. No cross-reactivity was detected with either analyte.

Applicazioni

For SMC: used for ultrasensitivite quantification of Human pTau217 in human serum, plasma, and cerebrospinal fluid.

Caratteristiche e vantaggi

This SMC^® kit features:

• Accurate and reproducible performance on the state-of-the-art SMCxPRO® ultrasensitive immunoassay system.
• Compatiblity with automated liquid handling

Altre note

SMC is a trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany

Note legali

SMC is a registered trademark of Singulex

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302 + H312 + H332,H319,H360FD,H373,H412
• Consigli di prudenza: P273 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 1B - STOT RE 2 Inhalation
• Organi bersaglio: Respiratory Tract
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3