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T-074

Supelco

3,3′,5-Triiodo-L-thyronine (T3) solution

100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®

Sinonimo/i:

3,3′,5-Triiodo-L-thyronine, O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T3

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About This Item

Formula empirica (notazione di Hill):
C15H12I3NO4
Numero CAS:
6893-02-3
Peso molecolare:
650.97
Beilstein:
2710227
Numero MDL:
MFCD00002593
Codice UNSPSC:
41116107
ID PubChem:
329826618
NACRES:
NA.24

Grado

certified reference material

Livello qualitativo

300

Forma fisica

liquid

Caratteristiche

Snap-N-Spike®/Snap-N-Shoot®

Confezionamento

ampule of 1 mL

Produttore/marchio commerciale

Cerilliant®

Concentrazione

100 μg/mL in methanol with 0.1N NH3

tecniche

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

Punto di fusione

234-238 °C (lit.)

applicazioni

clinical testing
clinical testing

Formato

single component solution

Temperatura di conservazione

−20°C

Stringa SMILE

N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O

InChI

1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
AUYYCJSJGJYCDS-LBPRGKRZSA-N

Informazioni sul gene

human ... THRA(7067) , THRB(7068)

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Categorie correlate

Descrizione generale

This Certified Spiking Solution® is suitable for use as a starting material in the preparation of linearity standards, calibrators, and controls for thyroid hormone testing methods by LC-MS/MS.

3,3′,5-Triiodo-L-thyronine (T3) is a thyroid hormone and active form of L-thyroxine (T4), formed by deiodinase type I or II. It supports various physiological functions, such as oxygen consumption, carbohydrate metabolism, protein synthesis, and neural development. Free and total T3 serum levels are measured by LC-MS/MS for the determination of hyperthyroidism caused by excess T3.

Applicazioni

The Certified Reference Material (CRM) in solution can also be used as follows:

  • Multi-residue determination of seven thyroid hormones in placenta samples by isotope dilution liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS)
  • Parts-per-trillion analysis of five thyroid hormones in zebrafish larvae by their solid phase extraction (SPE) and ultra-high performance liquid chromatography-electrospray ionization- tandem mass spectrometric (UPLC-ESI/MS/MS) analysis
  • Simultaneous analysis of six free thyroid hormones in bovine serum samples by ultrafiltration and high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS)
  • Determination of six thyroid hormones in mouse tissue samples by isotope dilution nano-ultraperformance liquid chromatography–quadrupole time-of-flight mass spectrometry (Q-TOF-MS)
  • Identification and quantification of triiodothyronine and thyroxine in rat serum samples using liquid chromatography-tandem mass spectrometry (LC-MS/MS)

Caratteristiche e vantaggi

  • Fully characterized under ISO/IEC 17025 and ISO 17034 accreditation
  • Accompanied with a comprehensive Certificate of Analysis (CoA) with data on stability, homogeneity, accuracy of concentration, uncertainty, and traceability
  • Rigorously tested through real-time stability studies to ensure accuracy and shelf life
  • Gravimetrically prepared using qualified precision balances to ensure minimal uncertainty
  • Flame sealed under argon into ampoules for long-term shelf life
  • Offered in a convenient, DEA-exempt format to improve laboratory efficiency

Note legali

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTIONS is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Avvertenze

Danger

Indicazioni di pericolo

H225,H301 + H311 + H331,H370,H412

Classi di pericolo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Flam. Liq. 2 - STOT SE 1

Organi bersaglio

Eyes,Central nervous system

Codice della classe di stoccaggio

3 - Flammable liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

49.5 °F - closed cup

Punto d’infiammabilità (°C)

9.7 °C - closed cup

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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3,3′,5-Triiodothyronine-(tyrosine phenyl-13C6) hydrochloride 99 atom % 13C, 95% (CP)

Sigma-Aldrich

709611

3,3′,5-Triiodothyronine-(tyrosine phenyl-13C6) hydrochloride

L-Thyroxine ≥98% (HPLC)

Sigma-Aldrich

T2376

L-Thyroxine

Liothyronine United States Pharmacopeia (USP) Reference Standard

USP

1368008

Liothyronine

L-Thyroxine powder, BioReagent, suitable for cell culture

Sigma-Aldrich

T1775

L-Thyroxine

Vasiliki Michopoulos et al.
Fertility and sterility, 99(7), 2084-2091 (2013-03-20)
To determine whether cognitive behavior therapy (CBT), which we had shown in a previous study to restore ovarian function in women with functional hypothalamic amenorrhea (FHA), could also ameliorate hypercortisolemia and improve other neuroendocrine and metabolic concomitants of in FHA.
V N Buriak et al.
Likars'ka sprava, (5)(5), 58-63 (2013-03-29)
The paper deals with etiopathogenetic and clinical peculiarities, and also therapeutic methods during the pathological processes in the thyroid system in the childhood. The most common of these processes is the diffuse nontoxic goiter, which results in abnormality of metabolic
Min Kyong Moon et al.
European journal of endocrinology, 168(6), 805-810 (2013-03-21)
Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. A total of 100 euthyroid men (free triiodothyronine
Min Wang et al.
Neuro endocrinology letters, 34(1), 62-70 (2013-03-26)
To evaluate the poly(dextrogyr-levogyr) lactide acid-triiodothyronine (PDLLA-T3) seeded with Schwann cells conduit for repairing sciatic nerve defect. The rats were divided into three groups: autologous nerve transplantation (Group A), PDLLA-T3 + Schwann cells (Group B) and PDLLA + Schwann cells
Susana B Bravo et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2431-2441 (2013-03-30)
Mechanisms of thyroid physiology and cancer are principally studied in follicular cell lines. However, human thyroid cancer lines were found to be heavily contaminated by other sources, and only one supposedly normal-thyroid cell line, immortalized with SV40 antigen, is available.
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Protocolli

Online SPE/LC-MS Method for the Rapid Analysis of Thyroid Hormones in Plasma

Determination of the thyroid hormones T4, T3 and rT3 from plasma using an Ascentis Express RP-Amide cartridge to trap the analytes, and a Phenyl-Hexyl column to resolve them.

Online Solid Phase Extraction and LC-MS Analysis of Thyroid Hormones in Human Serum

Thyroid hormones play critical roles in the regulation of biological processes, such as growth, metabolism, protein synthesis, and brain development. For a clinical laboratory, fast and reliable measurements of total hormone levels are important for the diagnosis and monitoring of thyroid diseases.

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