870320P
Avanti
N-palmitoyl homocysteine (PHC)
Avanti Research™ - A Croda Brand 870320P, powder
Sinonimo/i:
N-palmitoyl homocysteine (ammonium salt)
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About This Item
Formula empirica (notazione di Hill):
C20H42N2O3S
Numero CAS:
Peso molecolare:
390.62
Codice UNSPSC:
12352211
NACRES:
NA.25
Prodotti consigliati
Stato
powder
Confezionamento
pkg of 1 × 25 mg (870320P-25mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand 870320P
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Stringa SMILE
[O-]C(C(NC(CCCCCCCCCCCCCCC)=O)CCS)=O.[NH4+]
InChI
1S/C20H39NO3S.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)21-18(16-17-25)20(23)24;/h18,25H,2-17H2,1H3,(H,21,22)(H,23,24);1H3
WUXWCXRWTBPUKZ-UHFFFAOYSA-N
Descrizione generale
N-palmitoyl homocysteine (PHC) is a pH sensitive head group modified lipid.
Applicazioni
N-palmitoyl homocysteine (PHC) has been used in the synthesis of micelle-encapsulated temozolomide (TMZ) and targeted rapamycin micelles (TRaM).
Azioni biochim/fisiol
Liposomes containing pH-sensitive molecules facilitate site-specific drug release in response to the change of pH in the surrounding serum. They deliver drugs or gene fragments into the cytoplasm through the endocytotic pathway. Unlike plain liposomes, pH-sensitive liposomes effectively protect drugs and other encapsulated contents such as enzymes, plasmids, proteins and peptides from being potentially degraded at the lysosomal level. They have a wide range of clinical applications such as a carrier of potent drugs for cancer, pulmonary and infectious diseases, a vaccine adjuvant and a vehicle for contrasting agents during imaging. In addition, pH-sensitive liposomes also facilitate the transport of nucleic acids during gene therapy. DOPE liposomes containing PHC deliver their contents at the early endosome.
Confezionamento
5 mL Amber Glass Screw Cap Vial (870320P-25mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Formation strategies, mechanism of intracellular delivery and potential clinical applications of pH-sensitive liposomes
Liu X and Huang G
Asian Journal of Pharmaceutical Sciences , 8(6), 319-328 (2013)
D Collins et al.
Biochimica et biophysica acta, 987(1), 47-55 (1989-12-11)
By combining dioleoylphosphatidylethanolamine (DOPE) with oleic acid (OA), palmitoylhomocysteine (PHC) or dipalmitoylsuccinylglycerol (DPSG) we have prepared pH-sensitive liposomes with different acid sensitivities. DOPE/OA liposomes are the most acid sensitive, while DOPE/DPSG liposomes are the least acid sensitive. Incubation of DOPE/OA
J Connor et al.
The Journal of cell biology, 101(2), 582-589 (1985-08-01)
We previously showed that liposomes composed of dioleoylphosphatidyl-ethanolamine and palmitoyl-homocysteine (8:2) are highly fusion competent when exposed to an acidic environment of pH less than 6.5. (Connor, J., M. B. Yatvin, and L. Huang, 1984, Proc. Natl. Acad. Sci. USA.
J Connor et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(6), 1715-1718 (1984-03-01)
Sonicated unilamellar liposomes containing phosphatidylethanolamine and palmitoylhomocysteine fuse rapidly when the medium pH is lowered from 7 to 5. Liposome fusion was demonstrated by (i) mixing of the liposomal lipids as shown by resonance energy transfer, (ii) gel filtration, and
Kayla Miller et al.
Nanomedicine (London, England), 11(6), 581-595 (2016-03-24)
Glioblastoma multiforme is a devastating disease with no curative options due to the difficulty in achieving sufficient quantities of effective chemotherapies into the tumor past the blood-brain barrier. Micelles loaded with temozolomide (TMZ) were designed to increase the delivery of
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