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857127P

Avanti

17:0 Lyso PA

1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt), powder

Sinonimo/i:

heptadecanoyl lysophosphatidic acid; 1-heptadecanoyl-sn-glycero-3-phosphate (sodium salt); PA(17:0/0:0); 17:0 LPA; 110679

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About This Item

Formula empirica (notazione di Hill):
C20H40O7PNa
Numero CAS:
799268-66-9
Peso molecolare:
446.49
Codice UNSPSC:
51191904
NACRES:
NA.25

Saggio

>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)

Forma fisica

powder

Confezionamento

pkg of 1 × 25 mg (857127P-25mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 857127P

Tipo di lipide

phospholipids
cardiolipins

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Categorie correlate

Descrizione generale

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA), a bioactive phospholipid is seen at a low level in plasma (~100 nM). It is usually formed during the synthesis of phospholipid of cell membranes. It is produced by various cells like, activated platelets, epithelial cells, leukocytes, neuronal cells and tumor cells.

Applicazioni

17:0 Lyso PA is suitable to use as an internal standard:
  • for mass spectrometric determination of lysophosphatidic acid molecular species in mouse peritoneal macrophages
  • in the quantification of the lipid species released from extended synaptotagmin 2 (E-SYT2) expressed in mammalian cells by liquid chromatography with tandem mass spectrometry (LC-MS/MS)
  • for the extraction of lipids from brain homogenate
  • to extract lipids from the stomach washing solution for the determination of lysophosphatidic acid in a mouse stomach fluid

Azioni biochim/fisiol

Lysophosphatidic acid (1- or 2-acyl-lysophosphatidic acid/LPA) modulates cell motility, proliferation, invasion, survival and production of growth factors via G protein-coupled receptor (GPCR).

Confezionamento

5 mL Amber Glass Screw Cap Vial (857127P-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Comunemente ordinati con questo prodotto

N° Catalogo
Descrizione
Determinazione del prezzo

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

No data available

Punto d’infiammabilità (°C)

No data available

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Polarization of macrophages toward M2 phenotype is favored by reduction in iPLA2\beta (group VIA phospholipase A2)
Ashley JW, et al.
The Journal of Biological Chemistry, 291(44), 23268-23281 (2016)
Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro
Afroz S, et al.
Prostaglandins & other lipid mediators, 135, 36-44 (2018)
Comprehensive phospholipid and sphingomyelin profiling of different brain regions in mouse model of anxiety disorder using online two-dimensional (HILIC/RP)-LC/MS method
Berkecz R, et al.
Journal of Pharmaceutical and Biomedical Analysis, 149, 308- 317 (2018)
Lysophosphatidic acid triggers apoptosis in HeLa cells through the upregulation of tumor necrosis factor receptor superfamily member 21
Dong Y, et al.
Mediators of Inflammation, 2017 (2017)
Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer
Schauder CM, et al.
Nature, 510(7506), 552-552 (2014)
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