857119P
Avanti
06:0 Lyso PA
Avanti Research™ - A Croda Brand
Sinonimo/i:
1-hexanoyl-sn-glycero-3-phosphate (ammonium salt); PA(6:0/0:0)
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About This Item
Formula empirica (notazione di Hill):
C9H22NO7P
Numero CAS:
Peso molecolare:
287.25
Codice UNSPSC:
51191904
NACRES:
NA.25
Prodotti consigliati
Descrizione
1-hexanoyl-2-hydroxy-sn-glycero-3-phosphate (ammonium salt)
Saggio
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
Forma fisica
powder
Confezionamento
pkg of 1 × 25 mg (857119P-25mg)
Produttore/marchio commerciale
Avanti Research™ - A Croda Brand
Tipo di lipide
cardiolipins
phospholipids
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Stringa SMILE
O[C@](COP([O-])(O)=O)([H])COC(CCCCC)=O.[NH4+]
Categorie correlate
Descrizione generale
Lysophosphatidic acid (LPA) belongs to a class of phospholipids, that has a glycerol backbone attached by a phosphate group, an aliphatic chain and a hydroxyl group. It has a phosphate group attached to sn-3 position, an aliphatic chain attached to sn-1 or sn-2 position and the hydroxyl group attached to the remaining sn-1 or sn-2 position. 06:0 Lyso PA/HHGP, belongs to the LPA (lysophosphatidic acid) family. It is a negatively charged single chain lipid.
Lysophosphatidic acid (LPA) has a free hydroxyl and phosphate moiety. It is hydrophilic and is not associated with the membrane. It is the major constituent of serum.
Applicazioni
06:0 Lyso PA (LPA) has been used in the structure-activity relationship (SAR) analysis with G-protein receptor GPR92. It has also been used in lipid assay in the treatment of serum-starved primary mouse embryonic fibroblast cells.
06:0 Lyso PA has been used to study the role of lipid binding to MxiM protein in co‐crystallization experiments.
Azioni biochim/fisiol
Lysophosphatidic acid (LPA) is the precursor for the synthesis of phospholipids in eukaryotes and prokaryotes. It acts as an intercellular signaling molecule. Activated platelets produce LPA. It plays a major role in tissue healing and wound regeneration. LPA binds to G-protein coupled receptors. It possesses mitogenic properties. LPA inhibits differentiation of neuroblastoma and myoblast, aids in neurotransmitter release and smooth muscle contraction. It is a potential biomarker for ovarian and gynecological cancers. It is implicated in the initiation of neuropathic pain.
Lysophosphatidic acid (LPA) participates in several biological functions. LPA stimulates platelet aggregation, chemotaxis, cytoskeleton rearrangement, Ca2+ mobilization and cell proliferation. 06:0 Lyso PA/HHGP possesses a micromolar binding affinity for global regulator of LEE (locus of enterocyte effacement) repressor (GrlR) and for β-lactoglobulin.
Confezionamento
5 mL Amber Glass Screw Cap Vial (857119P-25mg)
Note legali
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Codice della classe di stoccaggio
11 - Combustible Solids
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Identification and characterization of the lipid-binding property of GrlR, a locus of enterocyte effacement regulator
Jobichen C, et al.
The Biochemical Journal, 420(2), 191-201 (2009)
Structure and biochemical analysis of a secretin pilot protein
Lario PI, et al.
The Embo Journal, 24(6), 1111-1121 (2005)
Lysophosphatidic acid as a potential biomarker for ovarian and other gynecologic cancers
Xu Y, et al.
JAMA : The Journal of the American Medical Association, 280(8), 719-723 (1998)
Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI
Abramovici H, et al.
Molecular Biology of the Cell, 20(7), 2049-2059 (2009)
Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling
Inoue M, et al.
Nature Medicine, 10(7), 712-712 (2004)
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