QBD10763

t-Boc-N-amido-dPEG^®₂₄-acid

>95% (HPLC)

• Sinonimo/i: t-Boc-N-amido-PEG₂₄-COOH, t-Boc-N-amido-PEG₂₄-acid, t-Boc-PEG-acid, BocNH-PEG₁₀₀₀-acid, BocNH-​PEG₂₄-​CH₂CH₂COOH
• Formula empirica (notazione di Hill): C₅₆H₁₁₁NO₂₈
• Peso molecolare: 1246.47
• Numero MDL: MFCD21363324
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Saggio: >95% (HPLC)
• Forma fisica: solid or viscous liquid
• Impiego in reazioni chimiche: reaction type: Pegylations
• Architettura del polimero: shape: linear; functionality: heterobifunctional
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C

Descrizione

Caratteristiche e vantaggi

t-Boc-N-amido-dPEG₂₄-acid is a monodisperse PEG product that is useful for peptide synthesis. The 76-atoms-long dPEG spacer allows the introduction of a long, hydrophilic spacer onto either end of a peptide chain or on an amino acid side chain. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. The Boc protecting group removes easily with acids such as trifluoroacetic acid (TFA), HF, and trifluoromethane sulfonic acid (TFMSA). Peptide PEGylation imparts water solubility to hydrophobic peptide chains, expands the PEG-peptide conjugates′ hydrodynamic volumes (thus decreasing renal clearance), and protects PEGylated peptides from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the t-Boc-N-amido-dPEG_n-acid (n=4, 8, 12, 24, 36) product series.

Note legali

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable