A95502
7-Azaindole
98%
Sinonimo/i:
1H-Pyrrolo(2,3-b)pyridine
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About This Item
Formula empirica (notazione di Hill):
C7H6N2
Numero CAS:
Peso molecolare:
118.14
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
![1H-pyrrolo[3,2-c]pyridine AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/291/250/879d6f32-75bf-4a4a-a366-18cbd62dcc37/640/879d6f32-75bf-4a4a-a366-18cbd62dcc37.png)
![1H-Pyrrolo[2,3-c]pyridine AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/332/393/b23058ac-c477-42b5-9890-dc5c2af5cec7/640/b23058ac-c477-42b5-9890-dc5c2af5cec7.png)
![1H-pyrrolo[3,2-b]pyridine AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/276/658/7030377c-695d-4006-bbf3-fe99211bb7e7/640/7030377c-695d-4006-bbf3-fe99211bb7e7.png)
Livello qualitativo
Saggio
98%
Stato
solid
Punto di fusione
105-107 °C (lit.)
Stringa SMILE
c1cnc2[nH]ccc2c1
InChI
1S/C7H6N2/c1-2-6-3-5-9-7(6)8-4-1/h1-5H,(H,8,9)
MVXVYAKCVDQRLW-UHFFFAOYSA-N
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Categorie correlate
Applicazioni
A heterocyclic molecule that can be utilized as a pharmaceutical building block
Starting material in a recent synthesis of azaserotonin.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Alastair Donald et al.
Journal of medicinal chemistry, 50(10), 2289-2292 (2007-04-25)
6-phenylpurines were identified as novel, ATP-competitive inhibitors of protein kinase B (PKB/Akt) from a fragment-based screen and were rapidly progressed to potent compounds using iterative protein-ligand crystallography with a PKA-PKB chimeric protein. An elaborated lead compound showed cell growth inhibition
John J Caldwell et al.
Journal of medicinal chemistry, 51(7), 2147-2157 (2008-03-19)
Fragment-based screening identified 7-azaindole as a protein kinase B inhibitor scaffold. Fragment elaboration using iterative crystallography of inhibitor-PKA-PKB chimera complexes efficiently guided improvements in the potency and selectivity of the compounds, resulting in the identification of nanomolar 6-(piperidin-1-yl)purine, 4-(piperidin-1-yl)-7-azaindole, and
Xin Wang et al.
The Journal of organic chemistry, 71(10), 4021-4023 (2006-05-06)
A practical synthesis of a key pharmaceutical intermediate, 2-[(1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino]-5-fluoronicotinic acid (1), is described. To introduce the aminomethyl moiety of 2 via a palladium-catalyzed cyanation/reduction sequence, a regioselective chlorination of 7-azaindole via the N-oxide was developed. A highly selective monodechlorination of
Pei-Wen Wu et al.
Journal of the American Chemical Society, 128(45), 14426-14427 (2006-11-09)
We report the synthesis of 3-(2-aminoethyl)-5-ol-1H-pyrrolo[2,3-b]pyridine (7-azaserotonin), which may potentially serve as an agonist or antagonist of serotonin receptors. In alcohols, the solvent (e.g., ethanol) catalyzed proton-transfer reaction takes place for 7-azaserotonin in the excited state, resulting in dual emission.
Bruno Aleksander Martek et al.
Drug testing and analysis, 11(4), 617-625 (2019-02-08)
The high frequency of the synthetic cannabinoid receptor agonists (SCRAs) emergence renders this group of new psychoactive compounds particularly demanding in terms of detection, identification, and responding. Without the available reference material, one of the specific problems is differentiation and
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