A7205
3-Acetamidophenol
97%
Sinonimo/i:
3′-Hydroxyacetanilide
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About This Item
Formula condensata:
CH3CONHC6H4OH
Numero CAS:
Peso molecolare:
151.16
Beilstein:
907998
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22
Prodotti consigliati
Livello qualitativo
Saggio
97%
Forma fisica
crystals
Punto di fusione
145-148 °C (lit.)
Stringa SMILE
CC(=O)Nc1cccc(O)c1
InChI
1S/C8H9NO2/c1-6(10)9-7-3-2-4-8(11)5-7/h2-5,11H,1H3,(H,9,10)
QLNWXBAGRTUKKI-UHFFFAOYSA-N
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Categorie correlate
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Eye Irrit. 2 - Skin Irrit. 2
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 2
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
dust mask type N95 (US), Eyeshields, Gloves
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Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.
Y Qiu et al.
Advances in experimental medicine and biology, 500, 663-673 (2002-01-05)
M A Bae et al.
Molecular pharmacology, 60(4), 847-856 (2001-09-20)
Acetaminophen (AAP), a widely used analgesic drug, can damage various organs when taken in large doses. In this study, we investigate whether AAP causes cell damage by altering the early signaling pathways associated with cell death and survival. AAP caused
M A Tirmenstein et al.
The Journal of biological chemistry, 264(17), 9814-9819 (1989-06-15)
Acetaminophen (250 mg/kg) administered intraperitoneally to fasted, phenobarbital-induced mice produced hepatotoxicity. No hepatotoxicity was observed after the administration of the regioisomer 3'-hydroxyacetanilide (600 mg/kg). Similar levels of covalent binding to liver homogenates occurred in mice receiving either acetaminophen or 3'-hydroxyacetanilide
N G Palmen et al.
Toxicology, 84(1-3), 157-170 (1993-11-12)
A model system for the detection of reactive metabolites, using glutathione depletion after microsomal activation, has been described previously. We developed a battery of complementary test systems using rat liver microsomes for metabolism and aqueous glutathione solutions, human erythrocytes or
T G Myers et al.
Chemical research in toxicology, 8(3), 403-413 (1995-04-01)
Acetaminophen (4'-hydroxyacetanilide), a widely used analgesic/antipyretic drug, is hepatotoxic in large doses, whereas the m-hydroxy isomer of acetaminophen, 3'-hydroxyacetanilide, is not hepatotoxic. Both are oxidized by mouse liver cytochromes P-450 to reactive metabolites that bind covalently to hepatic proteins. Because
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