936596
1H-Isoindole-1,3(2H)-dione, 4-[(4-aminobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride
≥95%
Sinonimo/i:
4-((4-aminobutyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
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About This Item
Formula empirica (notazione di Hill):
C17H20N4O4 · xHCl
Numero CAS:
Peso molecolare:
344.37 (free base basis)
Numero MDL:
Codice UNSPSC:
12161600
NACRES:
NA.22
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Livello qualitativo
Saggio
≥95%
Forma fisica
powder or crystals
Colore
light yellow to yellow
Temperatura di conservazione
2-8°C
Stringa SMILE
Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCN)C3C2=O)CC1
Applicazioni
A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. A basic building block for making protein degrader library.
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Altre note
Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs
Note legali
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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