930520

Pomalidomide-PEG₂-C₂-NH₂ hydrochloride

≥95%

• Sinonimo/i: 1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-(2-aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
• Formula empirica (notazione di Hill): C₁₉H₂₄N₄O₆ · xHCl
• Numero CAS: 2245697-87-2
• Peso molecolare: 404.42 (free base basis)
• Numero MDL: MFCD32263424

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95%
• Forma fisica: powder
• Gruppo funzionale: amine
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCN)=CC=C3)=O)=O

Descrizione

Applicazioni

Pomalidomide-PEG₂-C₂-NH₂ hydrochloride is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Allows rapid conjugation with carboxyl linkers due to the presence of an amine group via peptide coupling reactions. It is also active for linker attachment via reductive amination, and a basic building block for development of a protein degrader library.

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Protein Degrader Building Blocks

Altre note

Targeted Protein Degradation by Small Molecules

Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable