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202487

Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average MN 550, methoxy, hydroxyl

Sinonimo/i:

Polyethylene glycol monomethyl ether

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About This Item

Formula condensata:
CH3(OCH2CH2)nOH
Numero CAS:
9004-74-4
Numero MDL:
MFCD00084416
Codice UNSPSC:
12162002
ID PubChem:
24852066
NACRES:
NA.23

Nome del prodotto

Poly(ethylene glycol) methyl ether, average Mn 550

Densità del vapore

>1 (vs air)

Tensione di vapore

0.05 mmHg ( 20 °C)

Stato

semisolid

PM

average Mn 550

Indice di rifrazione

n20/D 1.455

Viscosità

7.5 cSt(210 °F)(lit.)

Temp. transizione

Tm 20 °C

Densità

1.089 g/mL at 25 °C

Estremità Ω

hydroxyl

Estremità α

methoxy

Stringa SMILE

O(CCO)C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Applicazioni

Poly(ethylene glycol) methyl ether can be used as a pore-forming agent to prepare polysulfone membranes with enhanced hydrophilicity.

Poly(ethylene glycol) methyl ether-grafted polyamidoamine (PAMAM) dendrimers can be used as drug carrier systems for anticancer drugs.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

359.6 °F - closed cup

Punto d’infiammabilità (°C)

182 °C - closed cup

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Certificati d'analisi (COA)

Lot/Batch Number
MKCN8241
MKCL2387
MKCH8837
MKCF0413
MKCB0160V

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Polyethylene glycol dimethyl ether 500 (stabilised) for synthesis

Sigma-Aldrich

8.14171

Polyethylene glycol dimethyl ether 500

Smita K Pawar et al.
International journal of pharmaceutics, 436(1-2), 183-193 (2012-06-23)
Efficacy of anticancer drug is limited by the severe adverse effects induced by drug; therefore the crux is in designing delivery systems targeted only to cancer cells. Toward this objectives, we propose, synthesis of poly(ethylene glycol) (PEG)-doxorubicin (DOX) prodrug conjugates
Mark G P Saifer et al.
Molecular immunology, 57(2), 236-246 (2013-11-10)
The use of methoxypoly(ethylene glycol) (mPEG) in PEG conjugates of proteins and non-protein therapeutic agents has led to the recognition that the polymer components of such conjugates can induce anti-PEG antibodies (anti-PEGs) that may accelerate the clearance and reduce the
Jiani Zheng et al.
Langmuir : the ACS journal of surfaces and colloids, 28(37), 13261-13273 (2012-08-28)
Alginate/chitosan/alginate (ACA) hydrogel microcapsules were modified with methoxy poly(ethylene glycol) (MPEG) to improve protein repellency and biocompatibility. Increased MPEG surface graft density (n(S)) on hydrogel microcapsules was achieved by controlling the grafting parameters including the buffer layer substrate, membrane thickness
Mulu Z Tesfay et al.
Journal of virology, 87(7), 3752-3759 (2013-01-18)
We are developing oncolytic vesicular stomatitis viruses (VSVs) for systemic treatment of multiple myeloma, an incurable malignancy of antibody-secreting plasma cells that are specifically localized in the bone marrow. One of the presumed advantages for using VSV as an oncolytic
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
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Articoli

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds via Bio-orthogonal Click Reactions

Devising biomaterial scaffolds that are capable of recapitulating critical aspects of the complex extracellular nature of living tissues in a threedimensional (3D) fashion is a challenging requirement in the field of tissue engineering and regenerative medicine.

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