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180246

Sigma-Aldrich

2-Naphthoic acid

98%

Sinonimo/i:

2-Naphthalenecarboxylic acid

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About This Item

Formula condensata:
C10H7CO2H
Numero CAS:
93-09-4
Peso molecolare:
172.18
Beilstein:
972039
Numero CE:
202-217-8
Numero MDL:
MFCD00004101
Codice UNSPSC:
12352100
ID PubChem:
24850857
NACRES:
NA.22

Livello qualitativo

100

Saggio

98%

Forma fisica

powder

Punto di fusione

185-187 °C (lit.)

Solubilità

alcohol: soluble
diethyl ether: soluble
hot water: slightly soluble

Gruppo funzionale

carboxylic acid

Stringa SMILE

OC(=O)c1ccc2ccccc2c1

InChI

1S/C11H8O2/c12-11(13)10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,(H,12,13)
UOBYKYZJUGYBDK-UHFFFAOYSA-N

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Descrizione generale

2-Naphthoic acid (NPA) is a noncompetitive N-methyl-D-aspartate (NMDA) receptor inhibitor. The fluorescence spectra and electronic absorption of 2-naphthoic acid was studied.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
STBJ9524
STBJ9508
STBH2307
STBG1725V
S15811V

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Sigma-Aldrich

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6-Bromo-2-naphthoic acid

2-Naphthalenemethanol 98%

Sigma-Aldrich

187313

2-Naphthalenemethanol

2-Hydroxy-1-naphthoic acid 98%

Sigma-Aldrich

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2-Hydroxy-1-naphthoic acid

Naptalam PESTANAL®, analytical standard

Supelco

33371

Naptalam

An electronic spectral study of the influence of thermal and electronic processes on the determination of the excited singlet-state dissociation constants of 1-and 2-naphthoic acid.
Kovi PJ and Schulman SG.
Analytica Chimica Acta, 63(1), 39-52 (1973)
Han Yu et al.
Molecular pharmacology, 84(4), 541-550 (2013-07-23)
N-Methyl-D-aspartate (NMDA) receptors mediate excitatory synaptic transmission in the central nervous system and play important roles in synaptic development and plasticity, but also mediate glutamate neurotoxicity. Recently, 2-naphthoic acid (NPA) and its derivatives have been identified as allosteric, noncompetitive NMDA
V Krishnakumar et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 70(1), 201-209 (2007-09-08)
The solid phase mid FTIR and FT Raman spectra of 2-naphthoic acid (NA) and 6-bromo-2-naphthoic acid (BNA) have been recorded in the regions 4000-400 cm(-1) and 3500-100 cm(-1), respectively. The fundamental vibrational frequencies and intensities of the vibrational bands were
M J Melancon et al.
Drug metabolism and disposition: the biological fate of chemicals, 10(2), 128-133 (1982-03-01)
Urine was collected from four female rats for 3 days after two subcutaneous injections with 0.3 mg of 2-methyl[8-14C]naphthalene per kg. Of the 14C injected, 55% was found in the urine. The urine was solvent-fractionated into a toluene fraction (4.9%
Blaise Mathias Costa et al.
Neuropharmacology, 62(4), 1730-1736 (2011-12-14)
Over-activation of N-methyl-d-aspartate (NMDA) receptors is critically involved in many neurological conditions, thus there has been considerable interest in developing NMDA receptor antagonists. We have recently identified a series of naphthoic and phenanthroic acid compounds that allosterically modulate NMDA receptors
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