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139262

Sigma-Aldrich

4-Chlorophenylacetic acid

ReagentPlus®, 99%

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About This Item

Formula condensata:
ClC6H4CH2CO2H
Numero CAS:
1878-66-6
Peso molecolare:
170.59
Beilstein:
1072816
Numero CE:
217-521-6
Numero MDL:
MFCD00004344
Codice UNSPSC:
12352100
ID PubChem:
24848401
NACRES:
NA.22

Livello qualitativo

100

Nome Commerciale

ReagentPlus®

Saggio

99%

Punto di fusione

102-105 °C (lit.)

Solubilità

ethanol: soluble 100 mg/mL, clear, faintly yellow

Gruppo funzionale

carboxylic acid
chloro

Stringa SMILE

OC(=O)Cc1ccc(Cl)cc1

InChI

1S/C8H7ClO2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4H,5H2,(H,10,11)
CDPKJZJVTHSESZ-UHFFFAOYSA-N

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Categorie correlate

Descrizione generale

4-Chlorophenylacetic acid possess anticancer properties. It is a novel therapeutic agent which can be useful in prevention or treatment of estrogen-sensitive breast cancer. It acts as carbon and energy supplement and is degraded by Pseudomonas sp. strain CBS3.

Applicazioni

4-Chlorophenylacetic acid was used to study the mechanism of aerobic degradation of 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane by Ralstonia eutropha A5.

Note legali

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H312 + H332,H315,H319

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
02305BDV
02305BD
04502JH
09017HD
05331JZ

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Hay et al.
FEMS microbiology ecology, 31(3), 249-253 (2000-03-17)
Evidence is presented demonstrating the ability of Ralstonia eutropha A5 to degrade 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane (DDD) aerobically. Strain A5 was able to effect significant transformation of [(14)C]DDD: the hexane extractable radioactivity decreased to approximately 50% of the controls while more than 25%
Neil Sidell et al.
Cancer letters, 251(2), 302-310 (2007-01-12)
Treatment of estrogen-sensitive breast cancer with selective estrogen selective modulators (SERMs) and, more recently, aromatase inhibitors has met with wide success. However, antagonism of estrogen receptor (ER) activity in breast carcinomas by SERMs such as tamoxifen has been associated with
N Sidell et al.
British journal of cancer, 89(2), 412-419 (2003-07-17)
We have investigated the effects of the low-toxic retinoid, all-trans retinoyl beta-glucuronide (RAG) alone and in combination with the phenylacetate (PA) derivative 4-chloro-phenylacetate (4-CPA) on the human neuroblastoma cell line, LA-N-5. In vitro studies demonstrated that RAG and 4-CPA treatments
S Sawatsri et al.
International journal of cancer, 93(5), 687-692 (2001-07-31)
The aromatic fatty acid phenylacetate (PA) and its analogs have come under intense investigation due to their ability to cause the growth arrest of a variety of neoplasia, including human breast cancer. We have determined that PA and its halide
A Markus et al.
Journal of bacteriology, 160(2), 618-621 (1984-11-01)
In cell-free extracts from Pseudomonas sp. strain CBS3 the conversion of 4-chlorophenylacetate to 3,4-dihydroxyphenylacetate was demonstrated. By Sephacryl S-200 chromatography two protein fractions, A and B, were obtained which both were essential for enzyme activity. Fe2+ and NADH were cofactors
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