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Sigma-Aldrich

1-(3-Chlorophenyl)piperazine hydrochloride

99%

Sinonimo/i:

m-CPP

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About This Item

Formula empirica (notazione di Hill):
C10H13ClN2 · xHCl
Numero CAS:
65369-76-8
Peso molecolare:
196.68 (free base basis)
Numero CE:
265-718-0
Numero MDL:
MFCD00039032
Codice UNSPSC:
12352100
ID PubChem:
24847652
NACRES:
NA.22

Saggio

99%

Forma fisica

powder

Punto di fusione

210-214 °C (dec.) (lit.)

Solubilità

methanol: soluble

Stringa SMILE

Cl.Clc1cccc(c1)N2CCNCC2

InChI

1S/C10H13ClN2.ClH/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13;/h1-3,8,12H,4-7H2;1H
MHXPYWFZULXYHT-UHFFFAOYSA-N

Informazioni sul gene

rat ... Htr1a(24473)

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Categorie correlate

Descrizione generale

1-(3-Chlorophenyl)piperazine hydrochloride is sold as Ecstasy mimic tablets and is the major metabolite of the antidepressant medications trazodone and nefazodone.

Applicazioni

1-(3-Chlorophenyl)piperazine hydrochloride (CPP) has been used in determination of designer piperazines in urine specimens using GC-MS and LC-ESI-MS. CPP has been used to investigate the in vitro efficacy of newly synthesized compounds such as fluoroquinolones (norfloxacine and lomefloxacine) against Philasterides dicentrarchi .

Azioni biochim/fisiol

1-(3-Chlorophenyl)piperazine induces hypophagia in food-deprived and freely feeding rats. CPP has affinity for 11 neurotransmitter receptor binding sites in human brain membranes.
5-HT2c serotonin receptor agonist; metabolite of trazodone.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Consigli di prudenza

P261 - P305 + P351 + P338

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificati d'analisi (COA)

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Nan Zhang et al.
Journal of ethnopharmacology, 219, 23-30 (2018-03-17)
Cananga odorata essential oil, known as ylang-ylang essential oil (YYO), was commonly used in the aromatherapy for relaxation and mood adjusting use. In our previous study, YYO played anxiolytic effects on the mice in several behavioral tests that based on
G A Kennett et al.
British journal of pharmacology, 103(4), 2016-2020 (1991-08-01)
1. 1-3(Chlorophenyl)piperazine (mCPP) (5 mg kg-1, i.p.) inhibited 2 h food intake in rats previously deprived of food for one day. Ten 5-hydroxytryptamine (5-HT) antagonists given s.c. opposed this hypophagic response. Calculated ID50 values correlated significantly with reported affinities (r
A Hamik et al.
Biological psychiatry, 25(5), 569-575 (1989-03-01)
The affinity of 1-(m-chlorophenyl)piperazine (mCPP) for 11 neurotransmitter receptor binding sites was determined in human brain membranes. mCPP is essentially equipotent at all 5-hydroxytryptamine (5-HT) receptor subtypes (IC50 values ranging from 360 to 1300 nM). The drug displays similar affinity
Shawn P Vorce et al.
Journal of analytical toxicology, 32(6), 444-450 (2008-07-26)
Designer piperazines, such as 1-benzylpiperazine (BZP) and 1-(3-trifluoromethylphenyl)-piperazine (TFMPP), are widely available and have become popular party drugs throughout the world. Used in many countries as legal alternatives to methamphetamine and ecstasy, these designer piperazines exhibit several of the same
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