Passa al contenuto
Merck

SNCA

synuclein, alpha (non A4 component of amyloid precursor)

Sinonimi:
NACP, PARK1, PARK4, PD1
Specie:
Human SNCA (6622), Mouse Snca (20617), Rat Snca (29219), chicken SNCA (395393), Horse SNCA (100053270), domestic cat SNCA (101091694), dog SNCA (478478), cow SNCA (282857), sheep SNCA (100294604), domestic guinea pig Snca (100725375)
ID UniProtKB:
P37840, A8K2A4, Q13701, Q4JHI3, Q6IAU6
ID gene:
  • Human(6622) Summary: Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
  • Mouse(20617) synuclein, alpha
  • Rat(29219) synuclein, alpha (non A4 component of amyloid precursor)
  • chicken(395393) synuclein, alpha (non A4 component of amyloid precursor)
  • Horse(100053270) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic cat(101091694) synuclein, alpha (non A4 component of amyloid precursor)
  • dog(478478) synuclein, alpha (non A4 component of amyloid precursor)
  • cow(282857) synuclein, alpha (non A4 component of amyloid precursor)
  • sheep(100294604) synuclein, alpha (non A4 component of amyloid precursor)
  • domestic guinea pig(100725375) synuclein, alpha (non A4 component of amyloid precursor)
  • naked mole-rat(101700039) synuclein, alpha (non A4 component of amyloid precursor)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Descrizione
Reattività con
Applicazione
MABN389
Anticorpo anti-alfa-sinucleina aggregata, clone 5G4, clone 5G4, from mouse, purified by affinity chromatography,
Reattività con
human
Applicazione
ELISA
immunohistochemistry
western blot
MABN826
Anticorpo anti-fosfo-α-sinucleina (Ser129), clone 81A, clone 81A, from mouse,
Reattività con
human, mouse
Applicazione
electron microscopy
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
S5566
Anti-α-Synuclein antibody, Mouse monoclonal, clone Syn211, purified from hybridoma cell culture,
Reattività con
human, zebra finch
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
36-008
Anticorpo anti-α-sinucleina, clone Syn211, ascites fluid, clone Syn211, Upstate®,
Reattività con
human
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
AB5038
Anticorpo anti α-sinucleina, serum, Chemicon®,
Reattività con
human, rat
Applicazione
immunocytochemistry
immunohistochemistry
western blot

Proteins

Product Number
Descrizione
Specie
S7820
α-Synuclein human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Specie
human
AG938
Synuclein, α, recombinant human, ,
Specie
human
575001
α-Synuclein, Human, Recombinant, E. coli, ,
Specie
human
S1071
α-Synuclein A53T human, recombinant, expressed in E. coli, N-terminal histidine tagged, ≥90% (SDS-PAGE), lyophilized powder,
Specie
human
AG549
α-synuclein 61-140, human, ,
Specie
human

esiRNA

Product Number
Descrizione
Specie
EHU095611
MISSION® esiRNA, targeting human SNCA (1),
Specie
human
EHU140811
MISSION® esiRNA, targeting human SNCA (2),
Specie
human