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Merck

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

Sinonimi:
GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099
Specie:
Human GABBR2 (9568), Mouse Gabbr2 (242425), Rat Gabbr2 (83633), Zebrafish gabbr2 (560267), dog GABBR2 (481627), Horse GABBR2 (100063963), cow GABBR2 (517040), domestic cat GABBR2 (101093058), chicken GABBR2 (420979), domestic guinea pig Gabbr2 (100170764) ...Più
ID UniProtKB:
O75899, O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9
ID gene:
  • Human(9568) Summary: The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
  • Mouse(242425) gamma-aminobutyric acid (GABA) B receptor, 2
  • Rat(83633) gamma-aminobutyric acid (GABA) B receptor 2
  • Zebrafish(560267) gamma-aminobutyric acid (GABA) B receptor, 2
  • dog(481627) gamma-aminobutyric acid (GABA) B receptor, 2
  • Horse(100063963) gamma-aminobutyric acid (GABA) B receptor, 2
  • cow(517040) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic cat(101093058) gamma-aminobutyric acid (GABA) B receptor, 2
  • chicken(420979) gamma-aminobutyric acid (GABA) B receptor, 2
  • domestic guinea pig(100170764) gamma-aminobutyric acid (GABA) B receptor, 2
  • naked mole-rat(101719923) gamma-aminobutyric acid (GABA) B receptor, 2
  • sheep(101103544) gamma-aminobutyric acid (GABA) B receptor, 2
  • Domestic Rabbit(100346845) gamma-aminobutyric acid (GABA) B receptor, 2

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
1048200
Baclofen, United States Pharmacopeia (USP) Reference Standard,
Specie
human
PHR1682
Baclofen, Pharmaceutical Secondary Standard; Certified Reference Material,
Specie
human
B0200000
Baclofen, European Pharmacopoeia (EP) Reference Standard,
Specie
human
BP028
Baclofen, British Pharmacopoeia (BP) Reference Standard,
Specie
human
B5399
(±)-Baclofen, ≥98% (HPLC), solid,
Specie
human, rat

Small Molecule - Allosteric Modulator

N° Catalogo
Descrizione
Specie
C0987
CGP-13501, ≥98% (HPLC), solid,
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
P118
Phaclofen, solid,
Specie
human
A6566
2-Hydroxysaclofen, ≥98% (TLC), solid,
Specie
human
B5399
(±)-Baclofen, ≥98% (HPLC), solid,
Specie
human, rat
S166
Saclofen, solid,
Specie
mouse, human, rat
A2129
γ-Aminobutyric acid, ≥99%,
Specie
human, rat

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
AB2255
Anti-GABA B Receptor R2 Antibody, serum, from guinea pig,
Reattività con
bovine, canine, chimpanzee, horse, human, mouse, rat, rhesus macaque, rhesus monkey
Applicazione
immunohistochemistry
western blot
G9920
Anti-GABAB Receptor 2, affinity isolated antibody, lyophilized powder,
Reattività con
rat
Applicazione
western blot
HPA013820
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
HPA031684
Anti-GABBR2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reattività con
human
Applicazione
immunohistochemistry
AB5848
Anti-GABA B Receptor R2 Antibody, a.a. 42-54 rat, Chemicon®, from rabbit,
Reattività con
human, rat
Applicazione
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
N142
NO-711 hydrochloride, ≥98% (HPLC),
Specie
human
V8261
(±)-Vigabatrin, ,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EHU002331
MISSION® esiRNA, targeting human GABBR2,
Specie
human