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Merck

CHRNA3

cholinergic receptor, nicotinic, alpha 3 (neuronal)

Sinonimi:
LNCR2, NACHRA3, PAOD2
Specie:
ID UniProtKB:
ID gene:
  • Human(1136) Summary: This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
  • Mouse(110834) cholinergic receptor, nicotinic, alpha polypeptide 3
  • Rat(25101) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • Zebrafish(568467) cholinergic receptor, nicotinic, alpha 3
  • dog(482111) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • domestic cat(100037403) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • cow(282702) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • chicken(386578) cholinergic receptor, nicotinic, alpha 3
  • naked mole-rat(101701279) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • domestic guinea pig(100730977) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • sheep(101123239) cholinergic receptor, nicotinic, alpha 3 (neuronal)
  • Domestic Rabbit(100342666) cholinergic receptor, nicotinic, alpha 3 (neuronal)

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
(±)-Nicotine, ≥99% (TLC), liquid,
Specie
human, rat
Carbamoylcholine chloride, ≥98% (titration), crystalline,
Specie
human, mouse, rat
Tropisetron, solid, ≥98% (HPLC),
Specie
rat, human
(−)-Nicotine solution, 1.0 mg/mL, analytical standard, for drug analysis,
Specie
human, mouse, rat
(−)-Nicotine, ≥99% (GC), liquid,
Specie
human, mouse, rat

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
Cytisine, ≥99%, powder,
Specie
rat
(±)-Nicotine, ≥99% (TLC), liquid,
Specie
human, rat
Carbamoylcholine chloride, ≥98% (titration), crystalline,
Specie
human, mouse, rat
Mecamylamine hydrochloride, ,
Specie
human
Tropisetron, solid, ≥98% (HPLC),
Specie
rat, human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
Anti-CHRNA3 antibody produced in rabbit, affinity isolated antibody,
Reattività con
dog, human, rabbit
Applicazione
western blot
Monoclonal Anti-Nicotinic Acetylcholine Receptor (α1, α3, α5 Subunits) antibody produced in rat, clone mAb 35, purified immunoglobulin, buffered aqueous solution,
Reattività con
chicken, eel, human
Applicazione
immunohistochemistry

Small Molecule - Blocker

N° Catalogo
Descrizione
Specie
Tetraethylammonium chloride, ≥98% (titration),
Specie
human
Hexamethonium bromide, ,
Specie
human
Hexamethonium chloride, solid (hygroscopic),
Specie
human
Kynurenic acid, ≥98%,
Specie
rat, human

esiRNA

N° Catalogo
Descrizione
Specie
MISSION® esiRNA, targeting human CHRNA3,
Specie
human
MISSION® esiRNA, targeting mouse Chrna3,
Specie
mouse