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Merck

CHRM4

cholinergic receptor, muscarinic 4

Sinonimi:
HM4, M4R
Specie:
Human CHRM4 (1132), Mouse Chrm4 (12672), Rat Chrm4 (25111), chicken CHRM4 (423195), cow CHRM4 (512928), domestic cat CHRM4 (101088360), dog CHRM4 (611314), sheep CHRM4 (101114554), Domestic Rabbit CHRM4 (100008791), domestic guinea pig Chrm4 (100714736)
ID UniProtKB:
P08173, B2RPP4, Q0VD60, Q4VBK7
ID gene:
  • Human(1132) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. [provided by RefSeq, Jul 2008]
  • Mouse(12672) cholinergic receptor, muscarinic 4
  • Rat(25111) cholinergic receptor, muscarinic 4
  • chicken(423195) cholinergic receptor, muscarinic 4
  • cow(512928) cholinergic receptor, muscarinic 4
  • domestic cat(101088360) cholinergic receptor, muscarinic 4
  • dog(611314) cholinergic receptor, muscarinic 4
  • sheep(101114554) cholinergic receptor, muscarinic 4
  • Domestic Rabbit(100008791) cholinergic receptor, muscarinic 4
  • domestic guinea pig(100714736) cholinergic receptor, muscarinic 4
  • naked mole-rat(101726411) cholinergic receptor, muscarinic 4

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Small Molecule - Agonist

N° Catalogo
Descrizione
Specie
P6503
Pilocarpine hydrochloride, ≥99% (titration), powder,
Specie
human
A2251
Acetyl-β-methylcholine chloride, ≥98% (TLC), powder,
Specie
human
P6628
Pilocarpine nitrate salt, ≥98% (HPLC),
Specie
human
O100
Oxotremorine M, solid,
Specie
human
M104
(±)-Muscarine chloride hydrate, ≥98% (HPLC),
Specie
human

Small Molecule - Antagonist

N° Catalogo
Descrizione
Specie
B1390
Bisacodyl, analytical standard, for drug analysis,
Specie
human
T9778
Tropicamide, solid,
Specie
human
S1875
(−)-Scopolamine hydrobromide trihydrate, ≥98% (HPLC), powder,
Specie
human
A0257
Atropine sulfate salt monohydrate, ≥97% (TLC), crystalline,
Specie
human
S7882
(−)-scopolamina N-butilbromuro, ≥98% (TLC), powder,
Specie
human

Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
MAB1578
Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 18C7.2, clone 18C7.2, Chemicon®, from mouse,
Reattività con
monkey
Applicazione
immunohistochemistry
immunoprecipitation (IP)
western blot
ZMS1165
Anti-CHRM4 Antibody, clone 18C7.2 ZooMAb® Mouse Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human
Applicazione
ELISA
affinity binding assay
immunocytochemistry
western blot
SAB4300824
Anti-CHRM4 antibody produced in rabbit, affinity isolated antibody,
Reattività con
human, mouse, rat
Applicazione
western blot
MAB1576
Anti-Muscarinic Acetylcholine Receptor m4 Antibody, clone 17F10.2, purified antibody, clone 17F10.2, Chemicon®,
Reattività con
monkey, mouse, rat
Applicazione
immunocytochemistry
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

N° Catalogo
Descrizione
Specie
A8404
Amitriptyline hydrochloride, ≥98% (TLC), powder,
Specie
human
D4526
Doxepin hydrochloride, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
Specie
human

Small Molecule - Ligand

N° Catalogo
Descrizione
Specie
A138
Aminobenztropine, solid,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EMU046221
MISSION® esiRNA, targeting mouse Chrm4,
Specie
mouse