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91928

Supelco

2′,4′,6′-Trihydroxyacetophenone monohydrate

matrix substance for MALDI-MS, ≥99.5%

Synonym(s):

2-Acetylphloroglucinol, THAP

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50 MG
A$350.00

A$350.00

Estimated to ship on16 May 2025

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50 MG
A$350.00

About This Item

Linear Formula:
(HO)3C6H2COCH3·H2O
CAS Number:
249278-28-2
Molecular Weight:
186.16
Beilstein:
9288656
MDL number:
MFCD00149091
UNSPSC Code:
12000000
PubChem Substance ID:
329770099
NACRES:
NA.21

A$350.00

Estimated to ship on16 May 2025

Request a Bulk Order

grade

matrix substance for MALDI-MS

Quality Level

100

Assay

≥99.5% (HPLC)
≥99.5%

form

solid

analyte chemical class(es)

glycans, oligonucleotides, peptides, proteins

technique(s)

MALDI-MS: suitable

color

light yellow

mp

218-222 °C
219-221 °C (lit.)

cation traces

Ca: ≤200 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤50 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Na: ≤50 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

suitability

in accordance for UV test

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General description

MALDI-MS analyzes require highest purity matrices and reagents, as organic or trace metal contamination causes adverse effects during crystallization, ionization or measurement. Therefore, our portfolio of MALDI matrices and reagents such as 2′,4′,6′-Trihydroxyacetophenone monohydrate are designed to fulfill the demanding requirements of today′s challenging applications.

Application

2′,4′,6′-Trihydroxyacetophenone monohydrate has been used as a matrix for oligosaccharide and glycopeptide analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF).[1]
Used in MALDI analysis of acidic glycans and glyco­peptides in negative ion mode. Lower limit of detection than 6-aza-2-thiothimidine.[2]

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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Certificates of Analysis (COA)

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    BCBT0674

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    J Wang et al.
    Journal of agricultural and food chemistry, 47(5), 2009-2015 (1999-12-20)
    Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) is a powerful new technique that will have a great impact on food analysis. This study is the first to demonstrate the applicability of MALDI-MS to perform both qualitative and quantitative analyses of anthocyanins
    U Pieles et al.
    Nucleic acids research, 21(14), 3191-3196 (1993-07-11)
    We report the analysis and characterization of natural and modified oligonucleotides by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). The present technology was highly improved for this class of compounds by using a new matrix, 2,4,6-trihydroxy acetophenone, together
    Analysis of acidic oligosaccharides and glycopeptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
    Papac, Damon I., Anissa Wong, and Andrew JS Jones.
    Analytical Chemistry, 68.18, 3215-3223 (1996)
    D I Papac et al.
    Analytical chemistry, 68(18), 3215-3223 (1996-09-15)
    2,5-Dihydroxybenzoic acid (DHB) is the most commonly used matrix for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF) of oligosaccharides. Because acidic, sialylated oligosaccharides are detected at only the low picomole level with DHB, alternative matrices were screened to identify a
    Gerard Artigas et al.
    The Journal of organic chemistry, 80(4), 2155-2164 (2015-01-21)
    We describe the synthesis and characterization of ametantrone-containing RNA ligands based on the derivatization of this intercalator with two neamine moieties (Amt-Nea,Nea) or with one azaquinolone heterocycle and one neamine (Amt-Nea,Azq) as well as its combination with guanidinoneamine (Amt-NeaG4). Biophysical
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