91928

2′,4′,6′-Trihydroxyacetophenone monohydrate

matrix substance for MALDI-MS, ≥99.5%

• Synonym(s): 2-Acetylphloroglucinol, THAP
• Linear Formula: (HO)₃C₆H₂COCH₃·H₂O
• CAS Number: 249278-28-2
• Molecular Weight: 186.16
• Beilstein: 9288656
• MDL number: MFCD00149091
• UNSPSC Code: 12000000
• PubChem Substance ID: 329770099
• NACRES: NA.21

Properties

• grade: matrix substance for MALDI-MS
• Quality Level: 100
• Assay: ≥99.5% (HPLC); ≥99.5%
• form: solid
• analyte chemical class(es): glycans, oligonucleotides, peptides, proteins
• technique(s): MALDI-MS: suitable
• color: light yellow
• mp: 218-222 °C; 219-221 °C (lit.)
• cation traces: Ca: ≤200 mg/kg; Cd: ≤5 mg/kg; Co: ≤5 mg/kg; Cr: ≤5 mg/kg; Cu: ≤5 mg/kg; Fe: ≤5 mg/kg; K: ≤50 mg/kg; Mg: ≤5 mg/kg; Mn: ≤5 mg/kg; Na: ≤50 mg/kg; Ni: ≤5 mg/kg; Pb: ≤5 mg/kg; Zn: ≤5 mg/kg
• suitability: in accordance for UV test

Description

General description

MALDI-MS analyzes require highest purity matrices and reagents, as organic or trace metal contamination causes adverse effects during crystallization, ionization or measurement. Therefore, our portfolio of MALDI matrices and reagents such as 2′,4′,6′-Trihydroxyacetophenone monohydrate are designed to fulfill the demanding requirements of today′s challenging applications.

Application

2′,4′,6′-Trihydroxyacetophenone monohydrate has been used as a matrix for oligosaccharide and glycopeptide analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF).

Used in MALDI analysis of acidic glycans and glyco­peptides in negative ion mode. Lower limit of detection than 6-aza-2-thiothimidine.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves