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Ethylene glycol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Ethylene glycol, 1,2-Ethanediol

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About This Item

Linear Formula:
HOCH2CH2OH
CAS Number:
107-21-1
Molecular Weight:
62.07
Beilstein:
505945
MDL number:
MFCD00002885
UNSPSC Code:
41116107
PubChem Substance ID:
329749793
NACRES:
NA.24

grade

pharmaceutical primary standard

vapor density

2.1 (vs air)

vapor pressure

0.08 mmHg ( 20 °C)

autoignition temp.

752 °F

expl. lim.

15.3 %

manufacturer/tradename

USP

refractive index

n20/D 1.431 (lit.)

bp

195-198 °C

mp

−13 °C (lit.)

density

1.113 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OCCO

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Ethylene glycol USP Reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Propylene Glycol
  • Polyethylene Glycol 3350
  • Noncrystallizing Sorbitol Solution
  • Polyoxyl 40 Hydrogenated Castor Oil
  • Maltitol Solution
  • Sorbitol Solution
  • Sorbitol Sorbitan Solution
  • Dapagliflozin Propanediol

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H373

Hazard Classifications

Acute Tox. 4 Oral - STOT RE 2 Oral

Target Organs

Kidney

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

239.0 °F - open cup

Flash Point(C)

115 °C - open cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ethylene Glycol, Diethylene Glycol, and Triethylene Glycol in Ethoxylated Products
USP43-NF38: United States Pharmacopeia and National Formulary
United States Pharmacopeia, 39(4), 6733-6733 (2014)
Frank F J Simonis et al.
Magnetic resonance in medicine, 73(3), 1184-1189 (2014-03-26)
MR thermometry (MRT) is a noninvasive method for measuring temperature that can potentially be used for radio frequency (RF) safety monitoring. This application requires measuring absolute temperature. In this study, a multigradient-echo (mGE) MRT sequence was used for that purpose.
Robert Hess et al.
Archives of toxicology, 78(12), 671-680 (2004-09-17)
Upon ingestion ethylene glycol (EG, monoethylene glycol) is rapidly absorbed from the gastrointestinal tract, and depending on the severity of exposure signs of toxicity may progress through three stages. Neurological effects characterize the first step consisting of central nervous depression
Eurwin Suryana et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 37, 69-75 (2014-07-11)
Myelination is an essential process in human development that is carried out by oligodendrocytes in the central nervous system. Hypoxic-ischaemic (HI) brain injury can disrupt myelination by causing oxidative stress, inflammation and excitotoxicity, resulting in the loss of myelin as
Peter Mygind Leth et al.
Forensic science international, 155(2-3), 179-184 (2005-10-18)
Ethylene glycol (EG) can be found in many agents, such as antifreeze. Ingestion of EG may cause serious poisoning. Adults are typically exposed when EG is ingested as a cheap substitute for ethanol or in suicide-attempts. Children may be exposed
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