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USP

Diethylene glycol

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

2,2′-Oxydiethanol, 2-Hydroxyethyl ether, Bis(2-hydroxyethyl) ether, Diglycol

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About This Item

Linear Formula:
(HOCH2CH2)2O
CAS Number:
111-46-6
Molecular Weight:
106.12
Beilstein:
969209
MDL number:
MFCD00002882
UNSPSC Code:
41116107
PubChem Substance ID:
329749578
NACRES:
NA.24

API family

diethylene glycol

autoignition temp.

442 °F

expl. lim.

2-12.3 %

manufacturer/tradename

USP

density

1.118 g/mL at 25 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

OCCOCCO

InChI

1S/C4H10O3/c5-1-3-7-4-2-6/h5-6H,1-4H2

InChI key

MTHSVFCYNBDYFN-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Diethylene glycol USP reference standard suitable for use in specified USP compendial tests and assays.

Also used to prepare standard, system suitability, and standard stock solution for impurity analysis and identification according to the given below monographs of United States Pharmacopeia (USP):
  • Propylene Glycol
  • Glycerin
  • Polyethylene Glycol 3350

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

280.4 °F - closed cup

Flash Point(C)

138 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Glycerin
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 28(4), 2123-2123 (2020)
Nestor R Sosa et al.
Annals of emergency medicine, 64(1), 38-47 (2014-01-21)
Diethylene glycol is a toxic industrial solvent responsible for more than 13 mass poisonings since 1937. Little is known about the clinical spectrum, progression, and neurotoxic potential of diethylene glycol-associated disease because of its high mortality and the absence of
Joshua G Schier et al.
Journal of public health policy, 30(2), 127-143 (2009-07-15)
Diethylene glycol (DEG), an extremely toxic chemical, has been implicated as the etiologic agent in at least 12 medication-associated mass poisonings over the last 70 years. Why DEG mass poisonings occur remains unclear. Most reports do not contain detailed reports
Leo J Schep et al.
Clinical toxicology (Philadelphia, Pa.), 47(6), 525-535 (2009-07-10)
Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste. In addition to its use in a wide range of industrial products, it has also been involved in a number of prominent mass poisonings
J L Hébert et al.
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 59(5), 344-349 (1983-02-03)
Although acute poisoning with ethylene glycol (EG) used in antifreeze mixtures is well known in man, only a few reports have described acute intoxication with diethylene glycol (DEG) and only one has mentioned oxaluria. Furthermore, there is no experimental evidence
View All Related Papers

Protocols

GC Analysis of Glycols on Nukol™

99%; Glycerol, ≥99.5%; Tetraethylene glycol, 99%

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