75027
Dextran sulfate sodium salt
Synonym(s):
Sodium Dextran Sulfate
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About This Item
UNSPSC Code:
12352201
NACRES:
NA.25
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form
powder
mol wt
Mr ~4000
impurities
3-6% (sulfur content)
loss
≤10% loss on drying
color
colorless
useful pH range
6.0-8.0 (10 g/L)
solubility
H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow
storage temp.
room temp
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General description
Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.
Application
Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.
Biochem/physiol Actions
Dextran sulfate was able to inhibit the binding of platelet factor 4 to S aureus bacterial surface in a dose dependent manner.
Other Notes
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Krystin Krauel et al.
Blood, 117(4), 1370-1378 (2010-10-21)
A clinically important adverse drug reaction, heparin-induced thrombocytopenia (HIT), is induced by antibodies specific for complexes of the chemokine platelet factor 4 (PF4) and the polyanion heparin. Even heparin-naive patients can generate anti-PF4/heparin IgG as early as day 4 of
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