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67578

Sigma-Aldrich

Dextran sulfate sodium salt

Synonym(s):

Dextran Sulfate Sodium

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About This Item

UNSPSC Code:
12352201
NACRES:
NA.25

form

powder

loss

≤10% loss on drying

useful pH range

6.0-8.0 (10 g/L)

solubility

H2O: 100 mg/mL, clear, colorless to faintly greenish-yellow

storage temp.

room temp

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General description

Dextran is a polymer of anhydroglucose. It is composed of approximately 95% alpha-D-(166) linkages. The remaining (163) linkages account for the branching of dextran.

Application

Dextran sulfate is routinely used for the selective precipitation of lipoproteins, probe hybridization membrane-immobilized DNA, the release of DNA from DNA-histone complexes, and the inhibition of RNA binding to ribosomes.
Dextran sulfate is used as a diluent in in situ hybridization experiments to increase hybridization of probes to target sequences in tissues.

Other Notes

To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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The rate of nucleic acid annealing to cytological preparations is increased in the presence of dextran sulfate.
L L Lederman et al.
Analytical biochemistry, 117(1), 158-163 (1981-10-01)
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ImmunoFISH is a method combining immunolabelling (IL) with fluorescent in situ hybridisation (FISH) to simultaneously detect the nuclear distribution of proteins and specific DNA sequences within chromosomes. This approach is particularly important when analysing meiotic cell division where morphogenesis of

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