SML3529

GB83

≥98% (HPLC)

• Synonym(s): GB 83, GB-83, N-[(1S)-1-(Cyclohexylmethyl)-2-[[(1S,2S)-1-[(2,3-dihydrospiro[1H-indene-1,4′-piperidin]-1′-yl)carbonyl]-2-methylbutyl]amino]-2-oxoethyl]-5-isoxazolecarboxamide
• Empirical Formula (Hill Notation): C₃₂H₄₄N₄O₄
• CAS Number: 1252806-86-2
• Molecular Weight: 548.72
• MDL number: MFCD20926417
• UNSPSC Code: 12352200

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: CC[C@@H]([C@H](NC([C@@H](NC(C1=CC=NO1)=O)CC2CCCCC2)=O)C(N3CCC4(CC3)CCC5=C4C=CC=C5)=O)C
• InChI: 1S/C32H44N4O4/c1-3-22(2)28(31(39)36-19-16-32(17-20-36)15-13-24-11-7-8-12-25(24)32)35-29(37)26(21-23-9-5-4-6-10-23)34-30(38)27-14-18-33-40-27/h7-8,11-12,14,18,22-23,26,28H,3-6,9-10,13,15-17,19-21H2,1-2H3,(H,34,38)(H,35,37)/t22?,26-,28-/m0/s1
• InChI key: ZXMXAOYWSLZLQM-NZNGGYBSSA-N

Description

Biochem/physiol Actions

GB83 is a serum stable, potent and selective antagonist of human protease activated receptor 2 (PAR2)(IC50 = 2 µM) that reversibly inhibit PAR2 activation by both proteases and PAR2 agonists. GB83 prevented upregulation of PARs, ICAM-1, LOX-1, IL-8, and activation of MAP kinases by coagulation factor X (FXa) in atrial tissue slices

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable