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Key Documents

PLA0248

Sigma-Aldrich

Rabbit anti-BAP1 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Synonym(s):

BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase), BRCA1-associated protein 1, HUCEP-13, KIAA0272, UCHL2, cerebral protein 6, cerebral protein-13, hucep-6, ubiquitin carboxy-terminal hydrolase

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

grade

Powered by Bethyl Laboratories, Inc.

species reactivity

human

technique(s)

immunoprecipitation (IP): 5-10 μg/mg
western blot: 1:2,000- 1:10,000

accession no.

NP_004647.1

UniProt accession no.

Q92560

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... BAP1(8314)

Immunogen

The epitope recognized by PLA0248 maps to a region between residue 679 and 729 of human BRCA1-associated protein 1 using the numbering given in entry NP_004647.1 (GeneID 8314).

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

BRCA1-associated protein 1 (BAP1) functions as a C-terminal ubiquitin hydrolase and may be involved in the transduction of signals in the BRCA1 pathway. BAP1 is also implicated to be a tumor suppressor as defects in BAP1 are found in non-small cell lung cancer cell lines.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Marta Betti et al.
Genes, chromosomes & cancer, 54(1), 51-62 (2014-09-19)
Inherited loss-of-function mutations in the BAP1 oncosuppressor gene are responsible for an inherited syndrome with predisposition to malignant mesothelioma (MM), uveal and keratinocytic melanoma, and other malignancies. Germline mutations that were inherited in an autosomal dominant fashion were identified in
Han-Sae Lee et al.
Nature communications, 5, 5128-5128 (2014-10-07)
The INO80 chromatin-remodelling complex has been implicated in DNA replication during stress in yeast. However, its role in normal DNA replication and its underlying mechanisms remain unclear. Here, we show that INO80 binds to replication forks and promotes fork progression

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