N1537

NU7026

≥98% (HPLC), solid

• Synonym(s): 2-(Morpholin-4-yl)-benzo[h]chromen-4-one
• Empirical Formula (Hill Notation): C₁₇H₁₅NO₃
• CAS Number: 154447-35-5
• Molecular Weight: 281.31
• MDL number: MFCD06798345
• UNSPSC Code: 12352200
• PubChem Substance ID: 329818582
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: solid
• color: tan
• solubility: DMSO: soluble 3 mg/mL at 60 °C; H₂O: insoluble
• shipped in: wet ice
• storage temp.: 2-8°C
• SMILES string: O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4
• InChI: 1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2
• InChI key: KKTZALUTXUZPSN-UHFFFAOYSA-N

Description

Application

NU7026 has been used:

• as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
• in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
• to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells

Potent, ATP-competitive. IC₅₀ = 0.23 μM. Selectivity over other PI3K-related kinases (IC₅₀ = 13 μM for PI3K and >100 μM for ATM and ATR).

Biochem/physiol Actions

Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves