- Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides.
Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides.
Nature communications (2017-07-18)
Alessandro Zorzi, Simon J Middendorp, Jonas Wilbs, Kaycie Deyle, Christian Heinis
PMID28714475
摘要
The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a 'piggy-back' strategy in which peptides bind via a ligand to the long-lived serum protein albumin. In accordance with this strategy, we developed an easily synthesized albumin-binding ligand based on a peptide-fatty acid chimera that has a high affinity for human albumin (K
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