- Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates.
Antimicrobial agents and chemotherapy (2012-05-23)
Yasuhiro Horita, Takemasa Takii, Tetsuya Yagi, Kenji Ogawa, Nagatoshi Fujiwara, Emi Inagaki, Laurent Kremer, Yasuo Sato, Ryuji Kuroishi, Yoosa Lee, Toshiaki Makino, Hajime Mizukami, Tomohiro Hasegawa, Ryuji Yamamoto, Kikuo Onozaki
PMID22615274
摘要
The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- and extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro. Both DSF and DDC exhibited potent antitubercular activities against 42 clinical isolates of M. tuberculosis, including MDR/XDR-TB strains. Moreover, DSF showed remarkable bactericidal activity ex vivo and in vivo. Therefore, DSF might be a drug repurposed for the treatment of MDR/XDR-TB.