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Merck

1643419

USP

替米沙坦

United States Pharmacopeia (USP) Reference Standard

别名:

4'[(1,4'-二甲基-2′-丙基 [2,6'-双-1H-苯并咪唑 ]-1′-基)甲基 ] [1,1'-联苯基 ]-2-羧酸, BIBR 277

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About This Item

经验公式(希尔记法):
C33H30N4O2
分子量:
514.62
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24

等級

pharmaceutical primary standard

API 家族

telmisartan

製造商/商標名

USP

應用

pharmaceutical (small molecule)

形式

neat

儲存溫度

2-8°C

SMILES 字串

CCCc1nc2c(C)cc(cc2n1Cc3ccc(cc3)-c4ccccc4C(O)=O)-c5nc6ccccc6n5C

InChI

1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)

InChI 密鑰

RMMXLENWKUUMAY-UHFFFAOYSA-N

基因資訊

human ... AGTR1(185)

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一般說明

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

應用

Telmisartan USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

生化/生理作用

替米沙坦是一种非肽类 1 血管紧张素受体拮抗剂。

分析報告

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

其他說明

Sales restrictions may apply.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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其他客户在看

Mijeong Son et al.
Clinical therapeutics, 36(8), 1147-1158 (2014-07-07)
Rosuvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, and telmisartan, an angiotensin receptor blocker, are commonly prescribed in combination for the treatment of dyslipidemia accompanied by hypertension. However, the nature of the pharmacokinetic interaction between the 2 drugs is not clearly
Dominik Wincewicz et al.
Pharmacological reports : PR, 66(3), 436-441 (2014-06-07)
The potential effect of chronic treatment with telmisartan, an angiotensin type 1 receptor blocker (ARB) and partial agonist of peroxisome proliferator--activated receptor γ (PPARγ), on stress-related disorders is a matter of considerable interest. The existing data suggest that angiotensin II
Yi Li et al.
Biochemical pharmacology, 93(4), 461-469 (2015-01-13)
Mesenteric adipose tissue hypertrophy is unique to Crohn's disease while the molecular basis of the crosstalk between MAT and the intestinal inflammation is largely unknown. Telmisartan is an angiotensin II type 1 receptor blocker and a peroxisome proliferator-activated receptor-receptor-γ agonist
Muralikrishna Gangadharan Komala et al.
PloS one, 9(11), e108994-e108994 (2014-11-05)
Sodium glucose cotransporter 2 (SGLT2) is the main luminal glucose transporter in the kidney. SGLT2 inhibition results in glycosuria and improved glycaemic control. Drugs inhibiting this transporter have recently been approved for clinical use and have been suggested to have
Habib Eslami et al.
Neuroscience letters, 558, 31-36 (2013-11-12)
Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase

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