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等級
pharmaceutical primary standard
API 家族
loratadine
製造商／商標名
USP
應用
pharmaceutical (small molecule)
格式
neat
SMILES 字串
Clc1ccc2c(CCc3cccnc3\C2=C4\CCNCC4)c1
InChI
1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChI 密鑰
JAUOIFJMECXRGI-UHFFFAOYSA-N
基因資訊
human ... HRH1(3269)
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一般說明
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.
應用
Loratadine Related Compound A USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:
Also, for use with USP monographs such as:
- Loratadine Orally Disintegrating Tablets
- Loratadine Chewable Tablets
- Loratadine Capsules
生化／生理作用
Desloratadine is a selective and nonsedating histamine H1 receptor antagonist, an active metabolite of loratadine (Claritin), used to relieve hay fever and allergy symptoms with less drowsiness than other antihistamines; does not significantly inhibits cardiac K+ channels at clinically achievable blood levels. Free from antimuscarinic/anticholinergic effects.
分析報告
These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.
其他說明
Sales restrictions may apply.
法律資訊
Clarinex is a registered trademark of Schering Corp.
相關產品
产品编号
说明
价格
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
390.2 °F - Pensky-Martens closed cup
閃點（°C）
199 °C - Pensky-Martens closed cup
其他客户在看
Faraz Kazmi et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(4), 523-533 (2015-01-18)
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remained a mystery as to which
Eva Wex et al.
PloS one, 9(12), e116166-e116166 (2014-12-30)
Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction, plasma exudation and
Shigeru Hishinuma et al.
Biochemical pharmacology, 91(2), 231-241 (2014-07-30)
Differential binding sites for first- and second-generation antihistamines were indicated on the basis of the crystal structure of human histamine H1 receptors. In this study, we evaluated differences between the thermodynamic driving forces of first- and second-generation antihistamines for human
Jung Yeon Kim et al.
Biomedical chromatography : BMC, 29(3), 465-474 (2014-08-01)
The purpose of this study was to develop and validate an ultra-performance liquid chromatography method for simultaneous analysis of 20 antihistamines (illegal additives) in dietary supplements. The limits of detection and quantitation of the method ranged from 1.5 to 2.5
Yoko Nagaya et al.
Drug metabolism and pharmacokinetics, 29(5), 419-426 (2014-05-09)
In central nervous system drug discovery, cerebrospinal fluid (CSF) drug concentration (C(CSF)) has been widely used as a surrogate for unbound brain concentrations (C(u,brain)). However, previous rodent studies demonstrated that when drugs undergo active efflux by transporters, such as P-glycoprotein
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