推荐产品
product name
Discovery® C18 高效液相色谱柱, 5 μm particle size, L × I.D. 12.5 cm × 4.6 mm
材料
stainless steel column
品質等級
agency
suitable for USP L1
產品線
Discovery®
特點
endcapped
製造商／商標名
Discovery®
包裝
1 ea of
標籤範圍
12% Carbon loading
參數
≤70 °C temp. range
400 bar pressure (5801 psi)
技術
HPLC: suitable
LC/MS: suitable
長度 × 內徑
12.5 cm × 4.6 mm
表面積
300 m2/g
表面覆盖率
3 μmol/m2
雜質
<10 ppm metals
基質
silica gel, high purity, spherical particle platform
fully porous particle
基質活性組
C18 (octadecyl) phase
粒徑
5 μm
孔徑
180 Å
工作pH值範圍
2-8
應用
food and beverages
分離技術
reversed phase
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一般說明
Discovery® C18 可用于针对 C18 的任何方法。该色谱柱具有对称的峰形、优良的重现性和稳定性等特点，适用于所有常规和高要求的 C18 方法，是此类方法的理想选择。
應用
- Rat Pharmacokinetics and In Vitro Metabolite Identification of KM-819, a Parkinson′s Disease Candidate, Using LC-MS/MS and LC-HRMS.: This study underscores the utility of theDiscovery® C18 HPLC Column in pharmacokinetic profiling and metabolite identification of a novel therapeutic agent, demonstrating its critical role in the development of Parkinson′s disease treatments (Choi et al., 2024).
- Determination of 2,4-dimethylhydroxybenzene by chromatographic methods in forensic toxicological research of biological material.: Highlights the application of the Discovery® C18 HPLC Column in forensic toxicology, enhancing the detection and quantification of toxic substances within biological samples, vital for legal and medical investigations (Chernova et al., 2024).
- High-throughput microfluidic chip with silica gel-C18 channels for cyclotide separation.: Illustrates the integration of the Discovery® C18 HPLC Column in a microfluidic setting for efficient and high-throughput separation of cyclotides, offering advancements in peptide and protein analysis (Ebrahimi et al., 2023).
- Priestia megaterium Metabolism: Isolation, Identification of Naringenin Analogues and Genes Elevated Associated with Nanoparticle Intervention.: This research utilizes the Discovery® C18 HPLC Column for the advanced study of microbial metabolism under nanoparticle intervention, pushing the boundaries of biotechnological and pharmaceutical research (Al-Theyab et al., 2023).
- A practical strategy enabling more reliable identification of ginsenosides from Panax quinquefolius flower by dimension-enhanced liquid chromatography/mass spectrometry and quantitative structure-retention relationship-based retention behavior prediction.: Demonstrates the versatility of the Discovery® C18 HPLC Column in complex botanical analyses, particularly in enhancing the reliability of ginsenoside identification, crucial for the development of herbal medicinal products (Sun et al., 2023).
特點和優勢
- 优良的重现性
- 分析酸性和碱性化合物均可获得良好的峰形
- 稳定性好、低流失，适用于 LC-MS 分析
- 能够分离多肽和小分子蛋白质
- 与很多同类 C18 色谱柱相比，疏水性更小，因此分析速度更快
法律資訊
Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany
T Nagano et al.
Journal of dental research, 88(9), 823-828 (2009-09-22)
Mmp-20 and Klk4 are the two key enamel proteases. Can both enzymes process amelogenin to generate the major cleavage products that accumulate during the secretory stage of amelogenesis? We isolated Mmp-20 and Klk4 from developing pig teeth and used them
Yuan-Qing Xia et al.
Rapid communications in mass spectrometry : RCM, 20(12), 1831-1837 (2006-05-18)
A major challenge in selecting an appropriate stationary phase for diastereomeric separation is that it is difficult to predict which of the commercially available stationary phases could achieve the required liquid chromatographic (LC) separation. This work describes the selection and
T R Shantha Kumar et al.
Journal of pharmaceutical and biomedical analysis, 38(1), 173-179 (2005-05-24)
A simple, precise and accurate isocratic reverse-phase liquid chromatography method with programmed wavelength detection has been validated to quantify DRF-4367 and Phenol red, simultaneously for application in rat in situ single pass intestinal perfusion study to assess intestinal permeability of
Satoru Sonoke et al.
Cancer research, 68(21), 8843-8851 (2008-11-01)
The pharmacokinetics and antitumor activity of pegylated small interfering RNA (siRNA)/cationic liposome complexes were studied after systemic administration to mice. We designed pegylated-lipid carriers for achieving increased plasma concentrations of RNA and hence improved accumulation of RNA in tumors by
Yoshinori Masukawa et al.
Journal of lipid research, 49(7), 1466-1476 (2008-03-25)
Ceramides (CERs) in human stratum corneum (SC) play physicochemical roles in determining barrier and water-holding functions of the skin, and specific species might be closely related to the regulation of keratinization, together with other CER-related lipids. Structures of those diverse
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Discovery C18 and C8 HPLC Columns products offered
Discovery C18 and C8 HPLC Columns products offered
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