推荐产品
product name
Astec® CHIROBIOTIC® T2手性 HPLC色谱柱, 5 μm particle size, L × I.D. 15 cm × 4.6 mm
材料
stainless steel column
agency
suitable for USP L63
描述
HPLC column
產品線
Astec®
包裝
pkg of 1 ea
製造商／商標名
Astec®
參數
0-45 °C temperature
241 bar pressure (3500 psi)
技術
HPLC: suitable
LC/MS: suitable
長度 × 內徑
15 cm × 4.6 mm
基質
high-purity silica gel particle platform
fully porous particle
粒徑
5 μm
孔徑
200 Å
工作pH值範圍
3.8-6.8
分離技術
chiral
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一般說明
CHIROBIOTIC ® T 和 T2 以替考拉宁作为手性选择剂。它们对编号类别的分子提供独特的选择性，特别是未衍生的 α, β, γ以及环状氨基酸、N-衍生氨基酸、羟基羧酸、酸性化合物（包括羧酸和酚类）、小肽、中性芳香族分析物以及环状芳香族和脂肪族胺类。通常在手性冠醚或配体交换型 CSP 上获得的分离也可能在手性化合物 ® T 和 T2 上进行，但在更简单的流动相（如水-醇）中进行。此外，所有已知的 β-受体阻滞剂（氨基醇）和二氢香豆素均已消退。CHIROBIOTIC ® T 和 T2 的结合化学和载体颗粒的孔径不同，使其具有不同的选择性和制备能力。
- 键合相：替考拉宁
- 操作 pH 范围：3.8-6.8
- 颗粒直径：5、10 或 16μm
- 孔径：100Å (CHIROBIOTIC ® T) 或 200Å (CHIROBIOTIC ® T2)
應用
- High-performance liquid chromatographic enantioseparation of 2-aminomono- and dihydroxycyclopentanecarboxylic and 2-aminodihydroxycyclohexanecarboxylic acids on macrocyclic glycopeptide-based phases.: This research employs the Astec® CHIROBIOTIC T2 Chiral HPLC Column for the enantioseparation of various amino acids. The study highlights the column′s effectiveness in separating complex chiral molecules, demonstrating its application in the analysis of amino acids and related compounds in chemical and pharmaceutical research (Berkecz et al., 2009).
法律資訊
Astec is a registered trademark of Merck KGaA, Darmstadt, Germany
CHIROBIOTIC is a registered trademark of Sigma-Aldrich Co. LLC
Chromatography Liquid Chiral Separations
Xiao, T.L., et al.
Encyclopedia of Separation Science, 1-15 (2000)
Chromatographic Separations and Analysis: Macrocyclic Glycopeptide Chiral Stationary Phases
Berthod, A.
Comprehensive Chirality, 8, 227-262 (2012)
Ping Sun et al.
Journal of molecular structure, 890(1-3), 75-80 (2008-11-12)
A high performance liquid chromatographic method using macrocyclic glycopeptide chiral stationary phases (CSPs) was used to separate enantiomers of seven ruthenium(II) polypyridyl complexes. Among the five different CSPs, the Chirobiotic T2 was most effective and baseline separated all complexes. All
Chris Hamman et al.
Journal of chromatography. A, 1305, 310-319 (2013-07-31)
A rapid screening method to identify the best conditions for chiral separations is described. We analyzed a representative set of 80 racemic compounds against 25 different chiral stationary phases with three different mobile phases to identify the combination of columns
Sarangan Ravichandran et al.
Journal of chromatography. A, 1269, 218-225 (2012-08-25)
The enantioselective separations of the chiral oxazaphosphorines (R,S)-ifosfamide (IF), (R,S)-2-N-dechloroethyl-IF (2-DCE-IF) and (R,S)-3-N-dechloroethyl-IF (3-DCE-IF) were achieved on teicoplanin-based chiral stationary phase using isopropanol:methanol (60:40, v/v) as the mobile phase. Computational models of the teicoplanin and teicoplanin aglycon (TAG) chiral selectors
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