推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
IgG fraction of antiserum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
antigen 82-84 kDa
物種活性
mouse, human, rat
技術
indirect immunofluorescence: 1:100 using Rat1 cells
western blot (chemiluminescent): 1:1,000 using whole extract of human HeLa cells
western blot (chemiluminescent): 1:2,000 using whole extract of mouse NIH3T3 cells
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... ZYX(7791)
mouse ... Zyx(22793)
rat ... Zyx(114636)
一般說明
Zyxin (ZYX ), a zinc-binding phosphoprotein of ∼61kDa is located at focal adhesions and along the actin cytoskeleton. It has three LIM domains. This structural protein is located on human chromosome 7q34.
免疫原
synthetic peptide corresponding to amino acid residues 134-150 of human zyxin with N-terminal added cysteine conjugated to KLH. The corresponding sequence differs by one amino acid in mouse.
應用
Anti-Zyxin antibody has been used in fluorescence microscopy.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 papers)
Western Blotting (1 papers)
生化／生理作用
Zyxin (ZYX ) participates in the modulation of actin assembly at focal adhesions and stress fibers. It also regulates cell adhesion and cell cycle. Overexpression of ZYX is associated with melanoma. Suppression of ZYX prevents cell growth.
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells
Ghosh SK, et al.
Journal of the American Heart Association, 4(6), e001712-e001712 (2015)
Functional analysis of Zyxin in cell migration and invasive potential of oral squamous cell carcinoma cells Corrigendum in/10.3892/ijo. 2016.3702
Yamamura MN, et al.
International Journal of Oncology, 42(3), 873-880 (2013)
A cell culture model for investigation of Hirano bodies
Davis RC, et al.
Acta Neuropathologica, 115(2), 205-205 (2008)
Aniqua Rahman et al.
Molecular biology of the cell (2016-03-11)
During metastasis, cells can use proteolytic activity to form tube-like "microtracks" within the extracellular matrix (ECM). Using these microtracks, cells can migrate unimpeded through the stroma. To investigate the molecular mechanisms of microtrack migration, we developed an in vitro 3D
Richard C Davis et al.
Acta neuropathologica, 115(2), 205-217 (2007-11-06)
Hirano bodies are paracrystalline F-actin-rich aggregations associated with a variety of conditions including aging, and neurodegenerative diseases. The composition and structure of these inclusions have been described by immunohistochemistry and ultrastructure, respectively. However, studies of the physiological function and dynamics
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